www.iajpr.com Page2339 Indo American Journal of Pharmaceutical Research, 2014 ISSN NO: 2231-6876 Journal home page: http://www.iajpr.com INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH SYNTHESIS AND ANTI-CONVULSANT EVALUATION OF NEW BENZOTRIAZOLE DERIVATIVES N.Karthik Rao 1 , J.Prathyusha Reddy 2 , B.Srujana 1 , M.Ravali 1 , K.Navaneetha 2 , B.Venkateswara Reddy 2 , T.Divya 1 , V.Varun Kumar 1 , K.Venkata Ramana Reddy 3 1. Rosory College of Pharmacy, Hanasparthy, Warangal. 2. St.Pauls College of Pharmacy, Turkayamjal, Hayathnagar, R.R.Dist. 3. Sree Dattha Institute of Pharmacy, R.R.District. Andhra Pradesh. Corresponding author N.KarthikRao, Rosory College of pharmacy. Hanasparthy, Warangal, A.P, INDIA. Kathikraoph@gmail.com, 8121018250. Copy right © 2014 This is an Open Access article distributed under the terms of the Indo American journal of Pharmaceutical Research, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ARTICLE INFO ABSTRACT Article history Received 10/04/2014 Available online 25/05/2014 Keywords Benzotriazole; Ortho- Phenyl Di Amine; Anti-Convulsant Activity; Grand-Mal Epilepsy. A new series of benzotriazole aldehyde and ketone derivatives were prepared starting from ortho-phenyl di amine (OPDA) in five steps which includes dehydration, cyclization, acetylation, reaction with hydrazine hydrate and finally reacting with aromatic aldehydes or aromatic ketones groups. All these synthesized compounds were evaluated for anti- convulsant activity. The benzotriazole derivatives may show significant reduction in the hind limb tonic extensor phase, which is similar to Grand-mal epilepsy in humans; this may be due to the inhibition of voltage dependent Na+ channels. The Benzotriazole aldehyde derivatives showed better activity than benzotriazole ketone derivatives. Please cite this article in press as N.KarthikRao, et al. Synthesis and Anti-Convulsant Evaluation of New Benzotriazole Derivatives. Indo American Journal of Pharm Research.2014:4(05).