Sergeev Y, Mordovtseva V, Sergeev V (2017) Meyerson Phenomenon: Report of Three Cases. Int J Clin Dermatol Res. 5(6), 147-150. 147 OPEN ACCESS http://scidoc.org/IJCDR.php International Journal of Clinical Dermatology & Research (IJCDR) ISSN 2332-2977 Meyerson Phenomenon: Report of Three Cases Case Report Sergeev Y 1* , Mordovtseva V 2 , Sergeev V 3 1 Chair of Skin and Veneral Diseases, I.M. Sechenov First MSMU, Moscow, Russia. 2 Chair of Skin and Veneral Diseases with Cosmetology Course, IMST MGUPP, Moscow, Russia. 3 Society for Dermatoscopy and Optical Diagnosis of Skin, Moscow, Russia. *Corresponding Author: Sergeev Yury, Chair of Skin and Veneral Diseases I.M. Sechenov First MSMU, Moscow, Russia. E-mail: tosergeev@gmail.com Received: July 07, 2017 Accepted: August 04, 2017 Published: August 07, 2017 Citation: Sergeev Y, Mordovtseva V, Sergeev V (2017) Meyerson Phenomenon: Report of Three Cases. Int J Clin Dermatol Res. 5(6), 147-150. doi: http://dx.doi.org/10.19070/2332-2977-1700033 Copyright: Sergeev Y © 2017. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. Abstract Meyerson phenomenon represents an eczematous reaction around various types of melanocytic and non-melanocytic tumors. We present three cases of Meyerson phenomenon, including atypical variant, around three different melanocytic lesions. Keywords: Meyerson Phenomenon; Meyerson Nevus; Dermoscopy; Halo Eczema; Melanoma. Introduction First mention of the development of an eczematous reaction around melanocytic nevi dates back to 1971. At that time such reaction was regarded as an atypical pityriasis rosea with Koeb- ner phenomenon around the nevi [1]. Since then similar reac- tion, also called Meyerson’s phenomenon or halo eczema, has been described around various melanocytic (common acquired nevus, congenital nevus, dysplastic nevus, Spitz nevus, melano- ma) and non-melanocytic (sebaceous nevus, seborrheic kerato- sis, dermatoibroma, nevus lammeus, basal cell carcinoma and squamous cell carcinoma) tumors [2]. By now, different causes of Meyerson phenomenon have been proposed, including sunburns, atopic predisposition, chemotherapy and interferon-α treatment, but the exact reason of such reaction remains unknown [3, 4]. Meyerson phenomenon typically occurs as a symmetrical erythe- ma, vesiculation and scaling around one, some or all nevi of the patient. Lesions may be asymptomatic or pruritic and accompa- nied by eczema-like rash on healthy skin. More often Meyerson phenomenon occurs in males, locates on the trunk or proximal extremities [3-5]. The eczematous reaction doesn’t modify the dermoscopic structures of the lesion, but can make them look blurred [6]. Dermoscopic patterns mainly depend on type of the lesion around which Meyerson phenomenon occurs and are com- bined with typical features of eczema - dotted vessels, scales and yellow crusts [3]. Histopathology reveals spongiosis, vesiculation and parakeratosis in the epidermis and supericial inlammatory iniltration in the dermis, associated with lymphocytic exocytosis. Predominance of the CD4+ lymphocytes in the iniltrate accen- tuates the inlammatory nature of the Meyerson phenomenon [2, 6]. The eczematous reaction can last up to 12 weeks without treat- ment and relapse several times. Treatment modalities include ob- servation, topical steroids and excision of the nevus [2]. Case Report We report our experience with three cases of Meyerson phenom- enon. Case 1 A 34-year-old male presented to our clinic with a 2-week history of pruritus around a pigmented lesion on the left lank. The pa- tient denied any possible triggers. Physical examination revealed pronounced xerosis and multiple melanocytic nevi (congenital, common acquired and dysplastic). Lesion on the trunk was rep- resented by a brown macule 10x6 mm with scaly surface and ir- regular borders (Figure. 1a). Dermoscopic examination revealed a slightly asymmetric melanocytic tumor with a blurry silhouette due to scales (Figure. 1b). Three additional dome-shaped brown papules with symmetric halo eczema were present on the upper extremities (Figure. 2a). Dermoscopic examination revealed typi- cal melanocytic nevi with homogeneous and globular patterns, surrounded by erythema, dotted vessels, scales and yellow crusts (Figure. 2b). Topical steroid and moisturizing ointment were pre-