Global Journal on Advances in Pure & Applied Sciences Vol 4 (2014) 66-74 Selected Paper of 1st World Conference on Health Sciences (H-SCI 2014), 24-26 April 2014, Zeynep Sentido Hotel Convention Center, Antalya, Turkey The effect of streptozotocin induced diabetes mellitus on liver activity in mice Noman D. Salih *, Department of Clinical Laboratory Science, Institute of Medical Science Technology, Universiti Kuala Lumpur, Malaysia. G. Hanan Kumar, Department of Clinical Laboratory Science, Institute of Medical Science Technology, Universiti Kuala Lumpur, Malaysia. Rhim M. Noah, Department of Clinical Laboratory Science, Institute of Medical Science Technology, Universiti Kuala Lumpur, Malaysia. Raad K. Muslih, Secretary General, Arab Federation for Oil and Gas Technologies (AFOGT), Amman, Jordan. Suggested Citation: Salih, N., D., Kumar, G., H., Noah, R., M., & Muslih, R., K. The effect of streptozotocin induced diabetes mellitus on liver activity in mice, Global Journal on Advances in Pure & Applied Sciences [Online]. 2014, 04, pp 66- 74. Available from: http://www.world-education-center.org/index.php/paas Received October 09, 2013; revised December 09, 2013; accepted March 05, 2014. Selection and peer review under responsibility of Prof. Dr. Haluk Soran, Near East University, Cyprus. ©ϮϬϭϰ SPROC LTD. Academic World Education & Research Center. All rights reserved. Abstract This study was designed to investigate the biochemical changes of liver function occurring due to STZ-induced diabetes mellitus in mice. Animals made diabetic by a single ip injection of STZ (150mg/kg bw) and serum samples were collected after two, four and six weeks of injection. Alterations in blood glucose level, body weight, relative percentage of live weight, the biochemical activity of liver enzymes (ALP, ACP, AST, ALT, LDH), total bilirubin, and cholesterol levels were estimated. Significant decrease of body weight was found, significant increases in blood glucose sugar, the relative percentage of liver weight, levels of ALP, AST, LAT, bilirubin and cholesterol, and insignificant increase in the activity of ACP; while serum LDH was increased significantly by the second and fourth week but decreased at the sixth week. The study concluded that STZ-induced diabetes affects significantly the biochemical function of liver and causes disturbances in the activity of liver enzymes. Keywords: Streptozotocin, diabetes mellitus, liver enzymes, biochemical alterations. *ADDRESS FOR CORRESPONDENCE: Noman D. Salih, Department of Clinical Laboratory Science, Institute of Medical Science Technology, Universiti Kuala Lumpur, Selangor, Kajang 43000, Malaysia, E-mail address: numan_salih@yahoo.com