Original Research Article DOI: 10.18231/2394-2754.2017.0077 Indian Journal of Obstetrics and Gynecology Research 2017;4(4):350-355 350 To study the efficacy safety and compliance of iron sucrose in mild, moderate and severe anemia in antenatal patients Gourab Ranjan Tripathy 1,* , Anand Acharya 2 1 Assistant Professor, Dept. of Obstetrics & Gynecology, 2 Professor & HOD, Dept. of Pharmacology, Konaseema Institute of Medical Sciences & Research, Amalapuram, Andhra Pradesh *Corresponding Author: Email: anand_kims@yahoo.co.in Abstract Introduction: Anaemia is a major public health problems in developing world. Anaemia is a pathological condition in which the oxygen binding capacity of red cells is insufficient to meet the body’s need . Anaemia is the most common medical disorder complicating pregnancy. It may antedate pregnancy, often aggravated by pregnancy and delivery. More than 70% of pregnant women suffer from nutritional anaemia in South East Asia. Of all the anaemias diagnosed during pregnancy 75% are due to iron deficiency. The prevalence of anaemia is 55% among expectant mothers across the world and the incidence in India varies from 40 –90% according to WHO reports. Materials and Method: The prospective study was carried out in the department of obstetrics and Gynecology, in Konaseema institute of medical science Amalapuram during 2015 -16 to access the efficacy, safety and compliance of injectable iron sucrose in pregnancy with mild, moderate and severe iron deficiency anaemia for a period of 12 months from Nov 2015 to Nov 2016. Result: Among the total number of 104 patients studied, mean age of the study group was 25.4 ± 3.26 years. Teen age pregnancies with anaemia formed 5.7% of the study group. Most cases, i.e. 77.9% were between 20 – 30 years. Elderly gravidas comprised 16.4%. The mean Hb% on day of Admission was 7.670 gm% which raised to 10.388 on day 28 of completion of iron therapy. Thus the mean Hb rise on day 28 was 2.718 gm% which is statistically significant (p value being 0.000).The Hb level at 38 weeks of gestation is 9.162 which is significantly higher when compared with Hb value on the day of admission (p value being 0.000). Discussion: Haemoglobin values varied significantly with time between groups (interaction effect, p<.001). The change in haemoglobin from baseline was significantly higher on the 14 th (p=.004) and 28 th (p=.031) days. Ferritin values were higher in the patients receiving intravenous iron throughout pregnancy. No serious adverse drug reactions were observed. Fetal weight and hospitalization time were similar in the 2 groups. Blood transfusion was required for only one patient in the oral group. Thus, it is observed that iron deficiency anemia of pregnancy treated with the intravenous iron had restored iron stores faster and more effectively than oral iron with no serious adverse reactions. Keywords: Anaemia, Iron sucrose, Antenatal Received: 23 rd March, 2017 Accepted: 3 rd August, 2017 Introduction Anaemia is a major public health problems in developing world. Anaemia is a pathological condition in which the oxygen binding capacity of red cells is insufficient of meet the body’s need. (1) Anaemia is the most common medical disorder complicating pregnancy. It may antedate pregnancy, often aggravated by pregnancy and delivery. More than 70% of pregnant women suffer from nutritional anaemia in South East Asia. (2) Of all the anaemias diagnosed during pregnancy 75% are due to iron deficiency. (3) The prevalence of anaemia is 55% among expectant mothers across the world and the incidence in India varies from 40 –90% according to WHO reports. (1) According to WHO, anaemia contributes 40% of maternal deaths in third world countries and in India, it contributes for 10-15% of direct maternal deaths. (4) Iron deficiency anaemia is caused primarily by inadequate intake, faulty dietic habits, inadequate absorption, multiparity. Previous menorrhagia, worm infestation, chronic diarrhoea, chronic malaria, asymptomatic bacteriuria. The demand of iron increases markedly specially after the 2 nd trimester, which cannot be met by dietary source alone. The adult human body contains about 3-4 gm of Iron, or which about 60-70% is present in blood (Hb Iron) as circulating iron and rest as storage iron. (5) The total daily loss of iron of an adult is about 1 mg, and about 12.5 mg per 28 days in menstruating women. Iron requirement increases during pregnancy from 21 mg / day of standard Indian women to 35 mg/day in pregnant women. (4) Iron requirements during Pregnancy The iron requirement of pregnancy for a non-anaemic woman with Hb of 11 mg /dl and body weight of 50 kg can be calculated as follows: