Contents lists available at BioMedSciDirect Publications Journal homepage: www.biomedscidirect.com International Journal of Biological & Medical Research Int J Biol Med Res. 2014; 5(3): 4239-4245 Present Status of Antihypertensive Drugs associated with other Cardiovascular Diseases in Bangladesh a a,b a c Md. Sheam Biswas , Md. Reyad-ul-ferdous, *, Fariha Tasnim , Nahida Akhter , Md. Naimul Islam a and Mohsina Mukti a a Department of Pharmacy, North South University, Dhaka-1229, Bangladesh. b Department of Pharmacy, Progati Medical Institute, Dhaka-1207, Bangladesh. c Department of Pharmacy, International Islamic University Chittagong, 154/A, College Road, Chittagong-4203, Bangladesh. A R T I C L E I N F O ABSTRACT Keywords: Antihypertensive Drugs Cardiovascular Diseases Bangladesh Original Article Aims: To correlate treatment management of anti-hypertension and cardiovascular diseases. Methods: In this studied a cross sectional observational was done on 200 patients among them 152 were male and 48 were female to find out the commonly used drugs for the treatment of hypertension and to determine the impact of different other risk factors on hypertension and associated cardiac diseases. Results: In this study a number of generics were found that included Beta blockers – Metoprolol (16%), Carvedilol (14%), Atenolol (6%); Calcium channel blocker – Amlodipine (17%); Diuretics – Furosemide + Spironolactone (16%); Angiotensin receptor blockers – Losartan (8%); ACE inhibitors – Ramipril (14%), Captopril (9%). An important observation is that Beta blockers are mostly used as antihypertensive. The prospect of Beta blocker is due to its compelling indication in post MI patients. Different other generics were also found that were used for the management of other cardiac problems. Among them antiplatelet agents like Aspirin + Clopidogrel (33%), Aspirin (6%) were predominant for the prevention of further heart attack, stroke and peripheral vascular disease. Lipid lowering agent like Atorvastatin (24%) was also found in a significant percentage. Other drugs were Vasodilator like Glyceryl trinitrate (23%), Cardiac glycocides like Digoxin (4%), Anti-ischemic like Trimetazidine HCl (7%) and Anticoagulants like Warfarin (3%). During the study other factors like sex, occupation, age, blood pressure (systolic and diastolic), number of prescribed drugs, associated other disease, side effect profile and table salt consumption considered. Conclusions: In this study we worked on various types of cardiovascular drugs and its effect on hypertension. From the study we saw that the patients are given different types of drugs such as Beta blocker, Calcium channel blocker, Diuretics etc. for lowering hypertension. The ultimate goal of this study was to find out the current prescription pattern of physicians for the management of hypertension. BioMedSciDirect Publications International Journal of BIOLOGICAL AND MEDICAL RESEARCH www.biomedscidirect.com Int J Biol Med Res 1. Introduction Copyright 2010 BioMedSciDirect Publications IJBMR - All rights reserved. ISSN: 0976:6685. c Hypertension has been recognized for decades as a major predictor of adverse effect such as stroke, heart failure, end-stage, renal disease, heart disease, and peripheral vascular disease. These estimates disease risk are the main components for the development and implementation of prevention, treatment, and control guidelines with a general theme of lower blood pressure levels associated with less adverse events [1]. Aerobic exercise and dietary modifications demonstrate to reduce blood pressure, randomized trials shows no effects of aerobic exercise combined with dietary modification on neurocognitive functioning in individuals with high blood pressure (i.e., pre-hypertension and stage 1 hypertension). Recent studies shows that, 124 participants with elevated blood pressure (systolic blood pressure 130 to 159 mm Hg or diastolic blood pressure 85 to 99 mm Hg) who were sedentary and overweight or obese (body mass index: 25 to 40 kg/m2) were randomized to the Dietary Approaches to Stop Hypertension (DASH) diet alone, a behavioral weight management program combined with exercise and caloric restriction or a usual diet control group. Participants completed neurocognitive tests including of executive function-memory-learning and Copyright 2010 BioMedSciDirect Publications. All rights reserved. c * Corresponding Author : Md. Reyad-ul-Ferdous Lecturer Department of Pharmacy Progati Medical Institute Dhaka-1207, Bangladesh. E-mail: rockyreyad@yahoo.com Mobile: +880-1719134213