Journal of Life Sciences Research ISSN(E) : 2408-9184 ISSN(P) : 2518-0126 Vol. 3, No. 4, 50-56, 2016 http://asianonlinejournals.com/index.php/Lifsc/index 50 A Modern View of the Pathogenesis of Allergy with Drug Etiology Iskandar Mavlyanov 1 Abdurashid Ashirmetov 2 Zafar Mavlyanov 3 Bekhzod Abdullaev 4  ( Corresponding Author) 1 MD, PhD of Clinic Pharmacology Department, Tashkent Medical Academy, Tashkent, Uzbekistan. 2 Researcher of Scientific Research Institute of Hematology and Blood Transfusion, Ministry of Health, Tashkent, Uzbekistan. 3 Senior research fellow of the Department of Clinical Pharmacology, Tashkent Medical Academy, Tashkent, Uzbekistan. 4 Scientific researcher, student of GP faculty, 4th year, Tashkent Medical Academy, Tashkent, Uzbekistan Abstract Nowadays many diseases are associated with a high risk of drug allergy, and this risk can vary greatly depending on the type of disease. With the progression of disease in HIV-infected patients is increased IgE and decreased the number of CD4+ T-cells. In this case violated the ratio of interferon-gamma-producing (Th1 type) clones of CD4+ T-cells and IL-4 - producing (Th2 type) clones of CD4+ T-cells. In HIV-infected patients, there is the high risk of developing allergies in the form of skin rashes and temperature, and severe skin syndromes Stevens-Jones (SJS) and toxic epidermal necrolysis (TEN) in 6%-10% of cases. CD4+ T cells secrete cytokines, for instance Interleukin (IL-5), Gransim and Eotaxin involve eosinophils to be grown and differentiated. Studies on the antigenicity of antibiotics demonstrated the potential relevance of both categories of drug allergy: hapten and p-i models. In patients with allergic reaction to piperacillin, this medication acts as the hapten, with the formation of the immunogenic conjugate piperacillin - albumin, which stimulates the drug-responsive T-cells. Immunogenetic factors have been identified as risk indicators for the development of hypersensitivity reactions to the representatives of many classes of drugs, such as Abacavir and Nevirapine, Carbamazepine and Allopurinol, etc. Thus, considering the huge genetic polymorphism in systems of drug metabolism in the body and in the systems contributing immune response to the resulting products of conjugation of hapten-protein, evident is the need to further study the role of these systems in the occurrence of adverse reactions to drug therapy, in particular, in the development of allergic complications. Keywords: Drug, Allergy, HIV, Antibiotics, HLA system, Hypersensitivity. Contents 1. Introduction ............................................................................................................................................................................................................ 51 2. Immunological Aspect ........................................................................................................................................................................................... 51 3. Antibiotics and Allergy ......................................................................................................................................................................................... 51 4. Viral Infection and Allergy ................................................................................................................................................................................... 51 5. Immune Reaction ................................................................................................................................................................................................... 52 6. Conclusion............................................................................................................................................................................................................... 53 7. Consent .................................................................................................................................................................................................................... 54 8. Ethical Approval .................................................................................................................................................................................................... 54 References ................................................................................................................................................................................................................... 54 Citation | Iskandar Mavlyanov; Abdurashid Ashirmetov; Zafar Mavlyanov; Bekhzod Abdullaev (2016). A Modern View of the Pathogenesis of Allergy with Drug Etiology. Journal of Life Sciences Research, 3(4): 50-56. DOI: 10.20448/journal.504/2016.3.4/504.3.50.56 ISSN(E) : 2408-9184 ISSN(P) : 2518-0126 Licensed: Contribution/Acknowledgement: This work is licensed under a Creative Commons Attribution 3.0 License We thank junior researchers Komila Porsokhonova and Tuychiboy Nishonov for their help in initiating and enriching the study. This study was not supported any financial organizations. Authors compensated all expenditures of article. Funding: This study received no specific financial support. Competing Interests: The authors declare that they have no conflict of interests. Transparency: The authors confirm that the manuscript is an honest, accurate, and transparent account of the study was reported; that no vital features of the study have been omitted; and that any discrepancies from the study as planned have been explained. History: Received: 1 August 2016/ Revised: 2 November 2016/ Accepted: 5 December 2016/ Published: 21 December 2016 Ethical: This study follows all ethical practices during writing. Publisher: Asian Online Journal Publishing Group