CORRELATION OF FOUR RE IN SUD 1,2,* Hala Ahmed Abd-A an 1 Sudan At 2 Atomic Energy Co 3 Department of Chemistry- ARTICLE INFO ABST Object stainin investi growth Mater cancer express Result lymph (47.9% 73 lym nodes positiv positiv positiv positiv and ins was po signific Conclu lymph Copyright © 2018, Hala Ahmed Abd-Alhadi et al. Th unrestricted use, distribution, and reproduction in any m INTRODUCTION It is known that some tumor markers are as invasion of tumors in their surrounding tissu to the lymph nodes and distant tissues l hepatocyte growth factor and integrins (C Martin et al, 2013). There are two types of e ERα and ERβ and they are nuclear receptor sequence of the two receptors is almost the s amino terminal. The estrogen receptors bind 17β etsradiol. Together the estrogens and the central role in the normal reproductive and the males and females. *Corresponding author: 1,2,* Hala Ahmed Abd-Alhadi, 1 Sudan Atomic Energy Commission- Khartoum- Sudan. 2 Atomic Energy Council- Sudan Academy of Sciences- K ISSN: 0975-833X V Article History: Received 21 st October, 2017 Received in revised form 19 th November, 2017 Accepted 08 th December, 2017 Published online 31 st January, 2018 Citation: Hala Ahmed Abd-Alhadi, Mohammed E Expression and Lymph Node Metastasis in Sudanese Key words: ER, PR, HER-2, VEGF, Metastasis to Lymph Nodes, Breast Cancer. RESEARCH ARTICLE ECEPTORS EXPRESSION AND LYMPH NO DANESE BREAST CANCER PATIENTS Alhadi, 1,3 Mohammed Elimam Ahamed M nd 1,2 Mohammed Ahmed Eltayeb tomic Energy Commission- Khartoum- Sudan ouncil- Sudan Academy of Sciences- Khartoum- Faculty of Science- King Khalid University- Ab TRACT tives: The aim of this study was to investigate the correlatio ng of four receptors and the metastasis of breast cancer to igated receptors were estrogen and progesterone receptor h factor-2 (HER-2) and vascular endothelial growth factor re rial and Methods: This study was retrospective study. O tissues were retrieved from the radiation and isotope sion of the receptors was investigated by immunohistochem ts: Forty eight samples (39.7%) were with negative lymph n node metastasis. Regarding the immunohistochemical stai %) out of the 48 lymph node negative tissues and it was posi mph node positive tissues. The PR positive staining results tissues were 17 (35.4%) and 22 (30.1%) respectively. T ve for HER-2 out of the 48 negative lymph node tissues ve tissues out of the 73 tissues with lymph node involvem ve in 17 (35.4%) of the lymph node negative tissues and ve lymph node metastasis. The spearman correlation showe significant correlation between ER, PR and VEGF and the ly ositive and insignificant correlation between HER and the cant positive correlation between the collective results and th usion: Collective staining results of ER, PR, HER and V node metastasis. his is an open access article distributed under the Creative Comm medium, provided the original work is properly cited. ssociated with the ues and metastasis like the CA15-3, Ceng et al, 2015; estrogen receptors; rs. The amino acid same except in the d estrogens like the eir receptors play a sexual function of . Khartoum- Sudan. Also they have many biologica males and females including immune and cardiovascular Progesterone receptors are nuc three types; A, C and B. The pr length receptor while the prog amino terminal truncated form binds the progesterone recept factor in milk ducts of the bre ovaries and reproductive tract Epidermal growth factor Rec member human epidermal gro HER-2, HER-3 and HER-4. I with 1255 amino acid. It activ differentiation and angiogenes and Naveed Iqbal, 2014) International Journal of Current Research Vol. 10, Issue, 01, pp.64420-64424, January, 2018 Elimam Ahamed Mohammed and Mohammed Ahmed Eltayeb, Breast Cancer Patients.”, International Journal of Current Researc Available online at http://www.journalcra.com ODE METASTASIS Mohammed - Sudan bha- Saudi Arabia on between the imunohistochemical the lymph nodes and the age. The r (ER and PR), human epidermal eceptor (VEGF). One hundred and twenty one breast centre in Khartoum (RICK). The mistry. nodes and 73 (60.3%) had positive ining of the ER was positive in 23 itive in 33 (45.2%) tissues out of the in the negative and positive lymph Thirty breast tissues (62.5%) were s compared to 57 (78.1%) HER-2 ment. Concerning the VEGF, it was in 25 (34.2%) of the tissues with ed that there was a weak, negative ymph node involvement while there lymph node metastasis. There was he lymph node metastasis. VEGF were useful as predictors for mons Attribution License, which permits al effects on different systems in g the muscloskeletal, nervous, r (Heldring et al, 2007). clear receptors and they are of rogesterone receptor B is the full gesterone receptor A and C are ms. The progesterone hormone tors and acts as a proliferative east and anti proliferative in the t (Daniel et al, 2011). Human ceptor -2 belongs to the four rowth factor receptors; HER-1, It is a trans membrane protein vates cell proliferation, survival, sis in many tissues (Nida Iqbal INTERNATIONAL JOURNAL OF CURRENT RESEARCH 2018. “Correlation of Four Receptors ch, 10, (01), 64420-64424.