Available online www.ijpras.com International Journal of Pharmaceutical Research & Allied Sciences, 2018, 7(1):126-132 Research Article ISSN : 2277-3657 CODEN(USA) : IJPRPM 126 The Effect of Whey Protein (Natural Nanoparticle) on Muscle Strength, GH, IGF, T. Protein and body composition Mohammed Nader Shalaby Lecturer of Biological Sciences and Sports Health Department, Faculty of Physical Education, Arish University, Egypt ________________________________________________________________________________________ ABSTRACT The aim of this study is to evaluate the effect of whey protein (natural nanoparticle) on muscle strength, GH, IGF1, T. Protein and body composition. It is hypotheses that there is a significant difference of pre-post whey protein administration on muscle strength, GH, IGF1, T. protein and body composition for the sake of post administration compared to control method: the researcher used the experimental method of two groups, one experimental (n = 10) the other control (n = 10), using whey protein (20 g/day) for 12 weeks, the control group used placebo. The sample study was composed of twenty college Students of faculty of Physical education, Arish University. Blood sample was withdrawn (10 ml) in a test tube for estimation of GH, IGF1, T1 protein, also the assessment of muscle strength of the upper and lower body, vertical jump tests together with body fat percent and body mass index, LBMY before and after whey protein and placebo administration. The researcher reaches the following conclusion: whey protein administration for 12 weeks significantly increased IGF1, T. protein, GH. Also, an improvement of the muscle strength of the upper body and lower body vertical jump together with a decreased body mass index and body fat percent, LBM% increase in control group there was non- change in the assessed variables. It is recommended to use whey protein in strength and competitive sports. Keywords: Whey protein, IGF1, T. protein, GH muscle strength and body composition _____________________________________________________________________________________________ INTRODUCTION Nanoparticles are solid particles of a size of 10-100 mm. The term was introduced by a Japanese engineer (Norio Taniguchi). The term "Nano" was derived from the Greek word "dwarf", and one nanometer (nm) equal one billion of a meter, which is about 6 carbon atoms [1]. Nano particles are classified to two major groups, organic and inorganic group. The organic one is divided to: liposomes, fullerenes, carbon nanotubes and polymeric. While inorganic in further divided to: quantum dots, ceramic and magnetic [2]. Many nanoparticles occur as natural products such as whey’s protein in human milk, lactose and Omega (3) (6) or may be engineered for application such as additives, nutritional supplements [3]. This research focuses on Nano sized particle which occur in nature, such as whey proteins as food supplement to explore its nutritional effect on the athletes. Two factors cause nanoparticles to behave significantly than bulk ones [4].