ISSN: 2320-5407 Int. J. Adv. Res. 6(3), 370-374 370 Journal Homepage: -www.journalijar.com Article DOI:10.21474/IJAR01/6688 DOI URL: http://dx.doi.org/10.21474/IJAR01/6688 RESEARCH ARTICLE THE PERIODONTAL DISEASE AND ITS RELATIONSHIP WITH PSYCHONEUROIMMUNOLOGY - A LITERATURE REVIEW. Jaqueline Alves do Nascimento 1 , Severino Alexandre Barbosa da Silva 1 , Janykelle Gonçalves de Lima 1 , Meirilandia Ribeiro da Costa 2 , Rayanne Maria Melo de Matos 2 , Jefferson David Melo de Matos 3 , Jozely Francisca Mello Lima 4 , Daniel Sartorelli Marques de Castro 5 and John Eversong Lucena de Vasconcelos 6 . 1. School of Dentistry, Centro Universitário UNILEÃO, Juazeiro do Norte – CE, Brazil. 2. Graduated in Dentistry, Centro Universitário UNILEÃO, Juazeiro do Norte – CE, Brazil. 3. Post Graduate Student - Masters Degree Program, Department of Prosthodontics Department, Universidade Estadual Paulista Júlio de Mesquita Filho UNESP, São José dos Campos - SP, Brazil. 4. Professor of Dental Prosthetics, Department of Dentistry, Faculdade Paulo Picanço, Fortaleza – CE, Brazil. 5. Professor of Dental Prosthetics, Department of Dentistry, Centro Universitário Christus - UNICHRISTUS, Fortaleza – CE, Brazil. 6. Professor of Oral Implantology, Department of Dentistry, Centro Caririense de Pós-Graduação CECAP, Juazeiro do Norte – CE, Brazil. …………………………………………………………………………………………………….... Manuscript Info Abstract ……………………. ……………………………………………………………… Manuscript History Received: 07 January 2018 Final Accepted: 09 February 2018 Published: March 2018 Keywords:- Periodontal Diseases, Dental Stress Analysis, Psychoneuroimmunology, Emotion. Aim: This work aims to show the relationship of periodontal disease with emotional and mental factors, with stress, personality and behavior and how these factors interfere in the body 's response to this disease. Methodology: It used the main databases: PUBMED, ScIELO, Google Scholar, Researchgate, with the following descriptors: Periodontal Disease, Dental Stress Analysis, Psiconeuroimunology, Emotion. Results: It was verified that emotional stress, personality, behavior and depression made possible a decrease in the production of immunoglobulin-A (IgA), alteration in the synthesis of cortisol and other glucocorticoids, which would make the individual more susceptible to a tissue destruction by substrates of bacterial order, and impaired immune system. Conclusion: Emotional and mental disorders, personality, behavior and depression are risk factors for the progression and installation of periodontal disease; since, once there are alterations in hormone synthesis, vascular alteration, bone metabolism with local factors associated with disease, the individual will be predisposed to it. Copy Right, IJAR, 2018,. All rights reserved. …………………………………………………………………………………………………….... Introduction:- Periodontal disease increasingly plagues the world's population. Emotional and mental disorders, alterations of genetic orders interconnected with secretions of hormones and neurotransmitters can provoke a physiological imbalance or in the homeostasis of the individual. Currently, studies indicate that stress, depression, behavior and personality of the individual and the negative effects of life have influence in periodontal disease by altering functions of the immune system response 1 . Corresponding Author:- Jaqueline Alves do Nascimento. Address:- School of Dentistry, Centro Universitário UNILEÃO, Juazeiro do Norte – CE, Brazil.