262 Minerva Urologica e nefrologica June 2017 major destructive and technically demanding procedure. Despite its known value in reduc- tion of the cancer speciic mortality and pro- viding 5-year disease speciic survival of 82%, 53% and 40% for T1, T2 and T3 tumors, re- spectively, 2 it has a considerable effect of the different aspects of patients’ life. This is at- H ealth related quality of life (HrQol) has become an important topic in recent medical practice. The concept of HRQOL has been sought as gold standard for weighting the beneits and costs of life-extending treatments and long-term care management. 1 radical cys- tectomy (rc) and urinary diversion (UD) is a ORIGINAL ARTICLE Health related quality of life after radical cystectomy in women: orthotopic neobladder versus ileal loop conduit and impact of incontinence Mohamed H. ZaHran 1 *, Diaa-Eddin TAHA 2 , Ahmed M. HARRAZ 1 , Essam M. ZIDAN 3 , Mona a. el-BilSHa 4 , Mohamed THARWAT 1 , Ahmed S. EL HEFNAWY 1 , Bedeir ali-el-Dein 1 1 Urology Department, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt; 2 Urology Department, Kafr El-Sheikh University, Kafr Elsheikh, Egypt; 3 Mental Health Department, Faculty of Education, Mansoura University, Mansoura, Egypt; 4 Mental Health Department, Faculty of Nursing, Mansoura University, Mansoura, Egypt *Corresponding authors: Mohamed H. Zahran, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt. e-mail: zahranmha@yahoo.com ABSTRACT BACKGROUND: Enough data about health related quality of life (HRQOL) after radical cystectomy (RC) and urinary diversion (UD) in women is still lacking. The objectives are to evaluate HRQOL in women after RC and orthotopic ne- obladder (onB) versus ileal loop conduit (ic) and to assess the impact of urinary continence. METHODS: The study included 145 women who underwent RC and came for routine follow-up. HRQOL was assessed by two questionnaires (EORTC-QLQ-C30and FACT-Bl). ONB group was stratiied to: totally continent, with nocturnal incontinence (NI) and patients in chronic urinary retention (CUR) and maintained on CIC. The orthotopic group (as a whole and its 3 subgroups) was compared to ic. RESULTS: ONB group included 22 continent women, 35 with NI and 27 in CUR and on CIC. There were no statistically signiicant differences between ONB and IC groups in all domains of the two questionnaires. However, continent women showed statistically signiicant better most of EORTC-QLQ-C30 scales and emotional well-being, functional well-being, bladder cancer subscale and FACT-Bl total Score (P˂0.05) than IC group. Similarly, women in CUR showed statistically signiicant better global health and physical functioning EORTC-QLQ-C30 scores (P values=0.0001, 0.01) and all do- mains of FACT-Bl. On the other hand, women with NI showed statistically signiicant lower values in all domains of the EORTC-QLQ-C30 and FACT-Bl than IC group. CONCLUSIONS: In women, HRQOL is better after ONB than IC as long as continence status is preserved. If inconti- nence is expected, IC may be a better option for UD. (Cite this article as: Zahran MH, Taha DE, Harraz AM, Zidan EM, El-Bilsha MA, Tharwat M, et al. Health related quality of life after radical cystectomy in women: orthotopic neobladder versus ileal loop conduit and impact of incontinence. Minerva Urol Nefrol 2017;69:262-70. DOI: 10.23736/S0393-2249.16.02742-9) Key words: Urinary diversion - Urinary reservoirs, continent - Urinary bladder neoplasms - Quality of life. Minerva Urologica e Nefrologica 2017 June;69(3):262-70 DOI: 10.23736/S0393-2249.16.02742-9 © 2016 eDiZioni Minerva MeDica online version at http://www.minervamedica.it COPYRIGHT © 2017 EDIZIONI MINERVA MEDICA This document is protected by international copyright laws. No additional reproduction is authorized. It is permitted for personal use to download and save only one file and print only one copy of this Article. It is not permitted to make additional copies (either sporadically or systematically, either printed or electronic) of the Article for any purpose. It is not permitted to distribute the electronic copy of the article through online internet and/or intranet file sharing systems, electronic mailing or any other means which may allow access to the Article. The use of all or any part of the Article for any Commercial Use is not permitted. The creation of derivative works from the Article is not permitted. The production of reprints for personal or commercial use is not permitted. It is not permitted to remove, cover, overlay, obscure, block, or change any copyright notices or terms of use which the Publisher may post on the Article. It is not permitted to frame or use framing techniques to enclose any trademark, logo, or other proprietary information of the Publisher.