_____________________________________________________________________________________________________ *Corresponding author: E-mail: okpanachigideon@gmail.com; Journal of Pharmaceutical Research International 22(1): 1-11, 2018; Article no.JPRI.39870 ISSN: 2456-9119 (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919, NLM ID: 101631759) Phytochemical Screening and Hypoglycemic Property of Globimetula braunii (Loranthaceae) Leaf Extracts Gideon O. Okpanachi 1,2* , Avosuahi R. Oyi 1 , Hassan Musa 1 , A. Abdulsamad 1 , Muhammad B. Sani 3 and Jamilu Ya’u 3 1 Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria. 2 Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Gombe State University, Gombe State, Nigeria. 3 Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria. Authors’ contributions This work was carried out in collaboration between all authors. Authors GOO, ARO, MBS and JY designed the study, performed the statistical analysis, wrote the protocol, and wrote the first draft of the manuscript. Authors HM and AA managed the analyses of the study. Author GOO managed the literature searches. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JPRI/2018/39870 Editor(s): (1) Rafik Karaman, Professor, Bioorganic Chemistry, College of Pharmacy, Al-Quds University, USA. Reviewers: (1) Julie S. Berame, De La Salle University & Caraga State University, Philippines. (2) Walter Antônio Roman Junior, University of the Region of Chapeco, Brazil. Complete Peer review History: http://www.sciencedomain.org/review-history/24145 Received 5 th December 2017 Accepted 13 th February 2018 Published 14 th April 2018 ABSTRACT Aims: To carry out phytochemical screening, acute toxicity test and to investigate the hypoglycemic potential of the ethanol extract and fractions of Globimetula braunii leaves. Place and Duration of Study: Department of Pharmacognosy and Drug Development and Animal House, Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria. August 2016 to April 2017. Methodology: The leaf powder (2.1 kg) was extracted with 7.0 L of ethanol using the infusion method. The extract obtained was further fractionated each with 2.7 L petroleum ether 60/80, ethyl Original Research Article