_____________________________________________________________________________________________________ *Corresponding author: E-mail: dr.moayyadalsalem@gmail.com; International Neuropsychiatric Disease Journal 10(2): 1-11, 2017; Article no.INDJ.37064 ISSN: 2321-7235, NLM ID: 101632319 Psychotropic Medication Non-adherence among Psychiatric Patients at King Abdulaziz Hospital- Makkah Moayyad Suliman Alsalem 1* 1 Department of Psychiatry, King Abdulaziz Hospital, Makkah, Saudi Arabia. Author’s contribution The sole author designed, analyzed and interpreted and prepared the manuscript. Article Information DOI: 10.9734/INDJ/2017/37064 Editor(s): (1) Pasquale Striano, Pediatric Neurology and Muscular Diseases Unit, University of Genoa, G. Gaslini Institute, Genova, Italy. Reviewers: (1) Dario Siniscalco, University of Campania, Italy. (2) Josef Finsterer, Austria. Complete Peer review History: http://www.sciencedomain.org/review-history/21789 Received 29 th September 2017 Accepted 1 st November 2017 Published 7 th November 2017 ABSTRACT Background: Non-adherence to psychotropic medication among psychiatric patients is one among the huge medical problem in Saudi Arabia. Most of the psychiatric patients do not adhere to the instruction of the physician in such a way that they reappear in the hospital after medication and getting well. Aim: To assess psychotropic medication non-adherence among psychiatric patients at King Abdulaziz hospital in Makkah city, Saudi Arabia. Methods: A cross-sectional study conducted on 342 psychiatric patients with age group between 18-65 years, and is visiting the outpatient clinics and subjected to psychotropic medication at the department of psychiatry at King Abdulaziz Hospital. Data were collected from the psychiatric patients using the designed questionnaire. The Medication Adherence Rating Scale (MARS) were used to assess the level of adherence to medication. Results: A total of 342 of patients participated in the study. One hundred ninety-one, 191(55.8%), were females. About half (54.4%) of the patients were married, (53.5%) of them were between 30- 39 years old. A significant relation between the educational level of participants and adherence to medication (P <0.05) were recorded. Patients in this study reported that the impacts of non- adherence to the medication are a relapse of the symptoms (25%), cannot sleep (15.2%), bad mood (10.2%), and agitation (4.7%). Original Research Article