Accepted Manuscript High single doses of radiation may induce elevated levels of hypoxia in early-stage non-small cell lung cancer tumors Olivia J. Kelada, PhD, Roy H. Decker, MD, PhD, Sameer K. Nath, MD, Kimberly L. Johung, MD, PhD, Ming-Qiang Zheng, PhD, Yiyun Huang, PhD, Jean-Dominique Gallezot, PhD, Chi Liu, PhD, Richard E. Carson, PhD, Uwe Oelfke, PhD, David J. Carlson, PhD PII: S0360-3016(18)30831-9 DOI: 10.1016/j.ijrobp.2018.05.032 Reference: ROB 25020 To appear in: International Journal of Radiation Oncology • Biology • Physics Received Date: 14 December 2017 Revised Date: 10 May 2018 Accepted Date: 13 May 2018 Please cite this article as: Kelada OJ, Decker RH, Nath SK, Johung KL, Zheng M-Q, Huang Y, Gallezot J-D, Liu C, Carson RE, Oelfke U, Carlson DJ, High single doses of radiation may induce elevated levels of hypoxia in early-stage non-small cell lung cancer tumors, International Journal of Radiation Oncology • Biology • Physics (2018), doi: 10.1016/j.ijrobp.2018.05.032. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.