IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 17, Issue 01 Ver. I January. (2018), PP 64-67 www.iosrjournals.org DOI: 10.9790/0853-1701016467 www.iosrjournals.org 64 | Page Measurement of C- reactive Protein and Platelets Indices in Hypertensive Sudanese patient in Khartoum state. *Albadawi Abdelbagi Talha 1 , Mohammed Siddig Younis 2 1 Faculty of Medical Laboratories Sciences University of Gezira, Wad Madani, Sudan. 2 Department of Medical Laboratory Technology, College of Medical Applied Science Taibah University, Almadina Almonawwarah, Saudi Arabia. Corresponding Author: Albadawi Abdelbagi Talha Abstract: Hypertension ,also known as high blood pressure or arterial hypertension, is a chronic medical condition in which the blood pressure in the arteries is persistently . Elevated C-reactive protein (CRP) , platelet count and mean platelet volume (MPV), have been associated in hypertensive patient. Objective: To determine C- reactive protein and platelets indices in hypertensive Sudanese patients. Materials and Methods: This cross sectional study was carried out in international hospital Khartoum state, Sudan during period from Dec 2015 up to Feb 2016. Seventy subjects were enrolled in the study, fifty as case study and twenty as case control. Assessment of C- reactive protein and platelets count and mean platelet volume in hypertensive patients by using hemoanalyzer Sysmex Results: There was significant value between hypertensive patient and age mean 54.42 and STD ±10.543, duration mean 5.11and STD ±4.263, gender mean 1.46 and STD ±503, platelets mean 355.28 and STD ±112.513, MPV mean 8.93 and STD ±1.901and CRP mean 1.192 and STD ±0.8523. Conclusions: The study confirms the existence of an association significant between hypertension in age, duration, platelets count, Mean platelet volume and C- reactive protein level and significant of CRP, Platelets count and MPV according to age and sex were reflecting on patient healthy stats. Keywords: C- reactive protein, Patelets count, Mean platelet volume ,Hypertensive --------------------------------------------------------------------------------------------------------------------------------------- Date of Submission: 23-12-2017 Date of acceptance:10-01-2018 --------------------------------------------------------------------------------------------------------------------------------------- I. Introduction Hypertension (HTN or HT), also known as high blood pressure or arterial hypertension,is a chronic medical condition in which the blood pressure in the arteries is persistently elevated. Blood pressure is expressed by two measurements, the systolic and diastolic pressures, which are the maximum and minimum pressures, respectively, in the arterial system (1) . The systolic pressure occurs when the left ventricle is most contracted; the diastolic pressure occurs when the left ventricle is most relaxed prior to the next contraction. Normal blood pressure at rest is within the range of 100–140 millimeters mercury (mmHg) systolic and 60–90 mmHg diastolic (2) . Hypertension is present if the resting blood pressure is persistently at or above 140/90 mmHg for most adults; different numbers apply to children (3) . High blood pressure develops cholesterol-rich build-ups (plaques) that line the blood vessel; these plaques can rupture and cause the platelets to form a clot. Even though no bleeding is occurring, platelets sense the plaque rupture and are confused, thinking that an injury has taken place that will cause bleeding. Instead of sealing the vessel to prevent bleeding as would occur with a cut, a clot forms in an intact blood vessel, causing a blockage of blood flow (4) . C-reactive protein (CRP), the prototypical acute-phase reactant, is one of the most widely known biomarkers of cardiovascular disease. Circulating levels of CRP are clinically used to predict the occurrence of cardiovascular events and to aide in the selection of therapies based on more accurate risk assessment in individuals who are at intermediate risk. In hypertensive individuals, CRP levels associate with vascular stiffness, atherosclerosis and the development of end-organ damage and cardiovascular events. Data suggest that some anti-hypertensive medications may lower CRP levels in a manner independent of their effect on blood pressure. In individuals who are normotensive at baseline, CRP levels have been shown in multiple cohorts to foretell the development of hypertension on follow-up (5) . Similarly to CRP, the platelet parameters are markers reflecting the systemic inflammatory response and activity/severity of many diseases (6, 7) . Moreover, such cells play an important and active role in the immune inflammatory response (8) . Platelet volume indices, such as mean platelet volume (MPV), an indicator of platelet size, and platelet distribution width (PDW), an index of platelet size heterogeneity, have been shown to be the markers of platelet function and activation (6, 7) .Higher MPV was associated with low-grade inflammatory conditions and a variety of risk factors of cardiovascular disorders (6, 9) . The aim of this study is to determine C- reactive protein and platelets indices in hypertensive Sudanese patients.