IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 17, Issue 01 Ver. VI January. (2018), PP 51-55 www.iosrjournals.org DOI: 10.9790/0853-1701065155 www.iosrjournals.org 51 | Page Study of Prevalence of Obstructive Sleep Apnea in Patients With Metabolic Syndrome *Dr. Vipparthi Suryakumari 1 , Dr. Venkatesh Vulli 2 , Dr. Gorantla Sambasiva Rao 3 , Dr. A.Anusha 4 , Dr. Vishnu 5 , Dr. T.Sateesh kumar 6 , Dr. J.Susmitha 7 1 Associate professor in the Department Of Pulmonary Medicine, Government Hospital for chest and communicable diseases, Andhra Pradesh, India 2 Senior resident in the department of pulmonary medicine, Andhra Medical College, Visakhapatnam, Andhra Pradesh, India. 3 Professor & HOD in the Department Of Pulmonary Medicine, Government Hospital for chest and communicable diseases, Andhra Pradesh, India. 4, 5 Post graduate in the department of pulmonary medicine, Government Hospital for chest and communicable diseases, Andhra Pradesh, India. 6, 7 Senior residents Corresponding author: Dr. T.Sateesh Kumar Abstract: Obstructive sleep apnoea (OSA) is the most common sleep disorder being diagnosed. It is a chronic condition that is characterized by repetitive episodes of the upper airway obstruction resulting in intermittent hypoxia and sleep fragmentation caused by arousals. Obstructive sleep apnea syndrome has been associated with an increased incidence of hypertension, stroke, and cardiovascular disease. Aim and Objectives: The aim was to determine the prevalence of Obstructive sleep apnoea in patients with metabolic syndrome and to determine whether OSA is associated with various components of metabolic syndrome. Methods: A hospital based cross-sectional study among 30 patients diagnosed with metabolic syndrome at department of endocrinology, Andhra Medical College, who were evaluated for OSA at Government Hospital for Chest and Communicable Diseases (GHCCD), Andhra medical college, Visakhapatnam, between March 2013 and September 2014 were included in the study. Results: out of 30 patients with metabolic syndrome, 18 were males and 12 were females. Of 30, 22 had OSA while 8 had no OSA. Among 22 OSA patients, 6, 3 and 13 patients have mild, moderate and severe OSA respectively. 19 out of 22 patients with hypertension, 14 out of 19 patients with diabetes, 17 out of 22 patients with hyper triglyceridemia and 10 out of 15 patients with low HDL levels have OSA. Conclussion: In conclusion, OSA is highly common in patients with metabolic syndrome and there was a significant association between components of MS and OSA. Early detection and treatment of OSA in MS can prevent the development of cardiovascular complications. Thus need for screening metabolic syndrome patients for undiagnosed OSA has been reinforced by this study. Keywords: OSA (Obstructive sleep apnoea), MS (Metabolic syndrome) -------------------------------------------------------------------------------------------------------------------------------------- Date of Submission: 28-12-2017 Date of acceptance: 16-01-2018 --------------------------------------------------------------------------------------------------------------------------------------- I. Introduction Short sleep duration and poor quality of sleep, increasingly common in our modern society, have many effects on our endocrine and metabolic function. Sleep is a major buffer for hormone release, glucose regulation and cardiovascular function [1]. Sleep-disordered breathing (SDB) disrupts sleep pattern and quality. Obstructive sleep apnoea (OSA) is the most common sleep disorder being diagnosed. It is a chronic condition that is characterized by repetitive episodes of the upper airway obstruction resulting in intermittent hypoxia and sleep fragmentation caused by arousals. Obstructive sleep apnea syndrome has been associated with an increased incidence of hypertension, stroke, and cardiovascular disease [2]. Metabolic syndrome (MS) was first described as a cluster of metabolic abnormalities, with insulin resistance as the central pathophysiological feature, and it was labelled as “Syndrome X” [3]. It is characterized by hypertension, abdominal obesity, increased triglycerides and blood glucose and decreased HDL cholesterol. Metabolic syndrome is associated with an increased risk for the development of type 2 diabetes mellitus and cardiovascular disease [4].