IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 17, Issue 1 Ver. 14 January. (2018), PP 41-48 www.iosrjournals.org DOI: 10.9790/0853-1701144148 www.iosrjournals.org 41 | Page Cyanoacrylate Vs Vitamin E Application after Laser Depigmentation: A Clinical Study. 1 Dr Rizwan M Sanadi, 2 Dr Urvashi Singh Professor, Department of Periodontology, Dr. G D Pol Foundation’s YMT Dental college and hospital. Post-graduate student, Department of Periodontology, G D Pol Foundation’s YMT Dental college and hospital. Address :- 403, pg girls hostel, ymt dental college and hospital, Institutional area, kharghar, sector-4, Corresponding Author: Dr Urvashi Singh Abstract Aim: To evaluate the clinical efficacy of Cyanoacrylate and Vitamin E application on healing after laser depigmentation procedure. Materials And Methods: Subjects having gingival melanin hyperpigmentation in maxillary and/or mandibular arches were selected as a part of split mouth study. Depigmentation procedure was performed using diode laser. Cyanoacrylate was applied on right side of the arches and vitamin E was applied on left side of the arches. Subjects were instructed to apply Vitamin E capsule on left side of the operated site thrice daily for three days. Subjects were recalled 1 week and 2 weeks post-operatively and Healing Index and Visual Analog Scale for pain and discomfort were recorded. Results: There was a statistically significant reduction in VAS scores for pain and discomfort and improvement in healing in both groups. Subjects in Cyanoacrylate group showed better healing. However, VAS scores were better for vitamin E group. Conclusion: Subjects having gingival melanin hyperpigmentation would show faster healing with laser depigmentation followed by use of Cyanoacrylate application. However, further long term studies with larger sample size are required to reach a definitive conclusion. Keywords: Cyanoacrylate, gingival hyperpigmentation, Vitamin E. --------------------------------------------------------------------------------------------------------------------------------------- Date of Submission: 12-01-2018 Date of acceptance: 29-01-2018 -------------------------------------------------------------------------------------------------------------------------------------- I. Introduction The individual's ability to exhibit a pleasing smile directly depends upon the quality of the dental and gingival elements that it contains, their conformity to the rules of structural beauty, the relations existing between the teeth and lips during smile and its harmonious integration in the facial composition. Melanin hyper-pigmented gingiva is an esthetic problem in many individuals, particularly if the hyper pigmentation is on the facial aspect of gingiva and visible during speech and mastication especially in patients with gummy smiles. Today's growing esthetic concerns among the patients require the removal of unsightly pigmented gingival areas to create an esthetically-pleasant-smile. A large number of parameters like the patient's skin color, the extent of gingival pigmentation, lip line, upper lip curvature and the esthetic concerns of the patient and his/her expectations from the treatment, play an important role in orchestrating the treatment plan 1 . Melanin pigmentation is the result of melanin granules produced by melanoblasts present at the basal layer of gingival epithelium. Gingiva is the most commonly affected site, followed by buccal mucosa, lips, palate, and tongue. Melanin pigmentation of gingiva is generally symmetric and it does not alter normal gingival architecture 2 . (Fig. 1) II. Classification Of Gingival Pigmentation Gingival pigmentation can be classified according to melanin index categories 3 . Class 0: No pigmentation. Class 1: Solitary unit(s) of pigmentation in papillary gingiva without extension between neighboring solitary units. Class 2: Formation of continuous ribbon extending from neighboring solitary units. Smile line 4 Analyzed by Liebart's classification: Class L: Very High Smile Line – >2 Mm Of The Marginal Gingiva Is Visible Or > 2 Mm Apical To The Cej Is Visible.