This open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 Li- cense (CC BY-NC 3.0). Downloaded from: www.jmp.iums.ac.ir 20 Journal of Medical Physiology. 2017; 2(1): 20-25. Original research The relationship of hemodynamic parameters with 6-month mortality in trauma patients; a prospective cohort study Mahmoud Yousefifard 1 , Babak Nakhjavan-Shahraki 2 , Arash Sarveazad 3 , Saeed Safari 4 , Mostafa Hosseini 5 * 1. Physiology Research Center and Department of Physiology, Faculty of Medicine, Iran University of Medical Sci- ences, Tehran, Iran. 2. Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran. 3. Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran. 4. Department of Emergency Medicine, Shohedaye Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 5. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Received: August 2016; Accepted: February 2017 Abstract: Background: Although the relationship between cardiovascular and respiratory parameters and mortality in trauma patients has been reported in studies, the findings have been contradictory in many cases. Therefore, the present study aimed to evaluate the relationship of systolic and diastolic blood pressures, heart and respiratory rates, arterial oxygen saturation and shock index with 6- month mortality of trauma patients. Methods: In a prospective cohort study, vital signs of the trauma patients presenting to emergency department were evaluated on admission. The patients were followed for 6 months and mortalities were recorded. Finally, using stepwise multivariate logistic regression test and reporting odds ratio (OR) with 95% confidence interval (CI) and multilevel, random intercept logistic regression models, the relationship between the evaluated factors and probability of death was assessed. Results: Data of 3158 patients with the mean age of 31.47±16.37 years (73.65% male) were evalu- ated. Apart from heart rate, the relationship of all the factors with probability of death was non- linear. The slope of mortality risk remained relatively constant with increase in heart rate, which means that with increase in heart rate, the probability of death also increased linearly (R2=0.98; p<0.0001). Probability of death in trauma patients is very low in respiratory rates less than 14; however, in higher rates, the probability rises significantly (R2=0.95; p<0.0001). In addition, re- garding arterial oxygen saturation level, probability of death is low in saturation levels over 90% but increases significantly when it is under 90% (R2=0.94; p<0.0001). Rise of the shock index to rates higher than 1 also increases the probability of death significantly (R2=0.93; p<0.000). When diastolic blood pressure is in the 70-90 mmHg range, probability of death is very low but it signifi- cantly rises in pressures less than this (R2=0.97; p<0.0001). A similar pattern exists regarding sys- tolic blood pressure, which indicates a low probability of death when systolic blood pressure is over 100 mmHg, yet the probability of death increases significantly when the pressure is lower than that (R2=0.93; p<0.0001). Conclusion: Findings of the present study showed that apart from heart rate, other evaluated fac- tors had an s-shape correlation with mortality in trauma patients. In other words, with little change in any of these factors, mortality risk of trauma patients can rise significantly. Therefore, continuous monitoring of blood pressure, heart rate, respiratory rate, and arterial oxygen saturation level in emergency departments is of great importance. Keyword: Trauma Severity Indices; Prognosis; Physiological Parameters Cite this article as: Yousefifard M, Nakhjavan-Shahraki B, Sarveazad A, Safari S, Hosseini M. The relationship of hemodynamic parameters with 6-month mortality in trauma patients; a prospective cohort study. J Med Physiol. 2017; 2(1):20-5.