IJSRSET1736211 | Received : 02 January 2018 | Accepted : 13 January 2018 | January-February-2018 [(4) 1 : 239-243] © 2018 IJSRSET | Volume 4 | Issue 1 | Print ISSN: 2395-1990 | Online ISSN : 2394-4099 Themed Section : Engineering and Technology 239 Serofrequency of Mumps Virus among Children with Type One Diabetes Mellitus Comparing to Control Group in Khartoum State Abeya Salah Ibrahim 1 , Wafa Ibrahim Elhag 2 , Nasr Mohamed Nasr 3 , Mohamed Hussein Arbab 4 1 MSc Student, Faculty of Medical Laboratory Sciences, Al Neelain University, Sudan 2 Associate professor, Faculty of Medical Laboratory Sciences, Microbiology Department, Al Neelain University, Sudan 3 Assistant professor, Omdurman Ahlia University, Microbiology Department, Sudan 4 Assistant professor of medical Microbiology Omdurman Ahlia University, Sudan ABSTRACT Background and Objectives: Epidemiological studies suggested that Mumps pancreatitis may associated with subsequent development of type one diabetes mellitus (T1D). This study was aimed to detect sero frequency of Mumps virus among children with T1D mellitus comparing to control group in Khartoum state. Methods: This was a descriptive case control study involve 90 children with T1D (Test group) and 90 healthy children (Control group) in Khartoum, patients aged between (1-5) years old, conducted in Omdurman Pediatric Teaching Hospital and Gaber Abo Eleiz Hospital - Khartoum State, Sudan, during February to September 2016. Mumps virus IgG for all participants was investigated using commercially available enzyme-linked immunosorbent assay (ELISA). Generated data were analyzed using SPSS and excel software programs. Results: The results revealed that the frequency of Mumps IgG were 23 (25.6%) and 3 (3.3%) among patients and control group respectively, also shown statistically significant relationship between Mumps virus infection and T1D with P- value (0.048). Conclusion: The seropositivity of Mumps virus among children with type one diabetes mellitus is significantly detected, further workup is required to co relate and confirmatory test and fellow up with large scale specimen is recommended. Keywords : Anti Mumps, Type I diabetes mellitus. I. INTRODUCTION Epidemiological studies have shown that many viral infections may develop auto immune type I diabetes mellitus (T1D), (1) . However, in 1986 and 1987, large outbreaks of Mumps infection occurred among immunized people born between 1967 and 1977, which was due to a single-dose of Mumps vaccine regimen that were develops type one diabetes mellitus (T1D) in a significant number of Mumps infected children’s (1) . This caused a shift in peak incidence from person’s age 5-9 years to those age 10- 19 years (2) , also several study were aimed to co – relates between many viruses infection and pancreatic auto reactivity that ultimately results in β- cell destruction resulting in insulin dependent T1D (1,2). It’s very clear now; that several viruses, such as certain Coxsackie virus’s species, Rubella virus as well as Mumps virus, are able to directly infect and lyses insulin-producing β-cells (4-6) . Thus, one mechanism by which viruses might induce T1D is through direct cytopathic effects, resulting in β-cell destruction and pancreatic cells death by auto reactive mimic antibodies (6) . The evidence for an involvement of Mumps viruses in triggering auto reactivity is of a different nature (6,7) . The destruction of insulin-