IJSRSET1844145 | Received : 13 March | Accepted : 24 March 2018 | March-April-2018 [(4) 4 : 571-575 ] © 2018 IJSRSET | Volume 4 | Issue 4 | Print ISSN: 2395-1990 | Online ISSN : 2394-4099 Themed Section : Engineering and Technology 571 Synthetic Strategy, Characterization and Antimycobacterium Evaluation of 8-Hydroxy Quinoline Derivatives Perumal Sarojini *1 , Malaichamy Jeyachandran 2 , Vagolusivakrishna 3 , Dharmarajan Sriram 3 1 Department of Chemistry, Sri S. Ramasamy Naidu Memorial College, Sattur, Virudhunagar, Tamil Nadu, India. 2 Post Graduate and Research Department of Chemistry, Sri Paramakalyani College, Alwarkurichi, Tirunelveli, Tamil Nadu, India 3 Department of Pharmacy,Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Jawahar Nagar, Hyderabad, India ABSTRACT 8-hydroxyquinoline derivatives are privileged structures for the design of new drug candidates. Due to its synthetic versatility, it holds many biological activities such as antibacterial, antifungal, immunosuppressive, analgesic, vasorelaxing, antiplasmodial, anticancer and antimycobacterium activity. In the present study, a series of 3-(substituted aryl)-1-(quinolin-8-yloxy) propan-2-ol were prepared and characterized. Primary in vitro screening of the synthesized compounds was performed against mycobacterium tuberculosis H37Ra. A significant decrease of mycobacterial cell metabolism (viability of M. tuberculosis H37Ra) was observed using MTB MABA assay. The structures of the compounds are elucidated with the aid of fourier transform infrared, proton nuclear magnetic resonance, carbon-13 nuclear magnetic resonance spectral techniques. Keywords: 8-hydroxyquinolines, Synthetic statergy, In vitro antimycobacterial activity, MTB MABA assay I. INTRODUCTION Tuberculosis is one of the world’s deadliest communicable diseases and challenging worldwide health problem. Global plan to stop the tuberculosis “stop TB”, WHO has estimated, 2006-2015, 1.3 million MDR-TB cases were treated in the 27 high MDR-TB burden countries between the years 2010- 2015 1 . It is estimated that between the years 2005 to 2020, one billion people will be newly infected, over 125 million people will get sick and 30 million will die of tuberculosis if control is not further strengthened 2. Mycobacterium tuberculosis is the pathogen responsible for TB 3 . Quinoline derivatives possess diverse pharmacological activities including antimicrobacterial, antitumour, caspase-3-inhibitors, anti-inflammatory activities 4-6 , antileishmanial 7,8 , antihypertensive, antirhythmics, schistomicidal activity, and cardiotonic activity 9-12 due to the broad range of biological activities. Quinoline compounds have been considered to be good starting materials for the search of novel pharmacological active compounds 13 . These compounds are interesting because they can perform as structurally related subunits in important biomolecules or biochemical process 14 . Among heterocyclic compounds, quinoline scaffold has become an important construction motif for the development of new drugs 15 . The interest in 8-hydroxyquinolines has grown exponentially in the last two decades as they are privileged structures for the design of new drug candidates that exert a host of biological effects on various targets 16 . The study of biological activities such as neuroprotection, anticancer, antibacterial, antifungal activity has been further promoted by the synthetic versatility of 8- hydroxyquinoline, which allows the generation of a large number of derivatives 17 . Quinoline is one of the most important N-based heterocyclic aromatic