IJSRST173728 | Received : 10 Sep 2017 | Accepted : 18 Sep 2017 | September-October-2017 [(3) 7: 146-152] © 2017 IJSRST | Volume 3 | Issue 7 | Print ISSN: 2395-6011 | Online ISSN: 2395-602X Themed Section: Science and Technology 146 A Glance on Zika Virus Infection Patil Priyanka A*, Dr. Magdum C. S., Dr. Singh S. K. Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Sangli, Maharashtra, India School of Pharmacy, Suresh Gyan Vihar University, Jaipur, Rajastan, India ABSTRACT Zika virus is mainly transmitted through its vector Aedes aegyti are now a days affecting the world population, this infection has also affected to the pregnant women, which causes microcephaly in their newborns. Zika virus infection also causes Guillain Barre syndrome GBS. Till date, there was no specific medication available for treatment of Zika virus infection. Some preventive measurements will be applicable. The Scientists are trying to investigate the vaccine which will be useful in future. Keywords: Zika Virus, Treatment, ZIKA. I. INTRODUCTION Zika virus was first isolated in the Zika Forest near Lake Victoria, Uganda in April 1947 from a sentinel rhesus monkey placed; in January 1948 a second isolation from the mosquito Aedes africanus followed at the same site .[1] Zika virus (ZIKV) infection has been a source of concern in the recent few months due to increase in the number of patients being affected by it with epidemic proportions in Brazil and its potential of spread to other countries. The association of microcephaly in newborns due to the Zika virus has further created panic and worry among the people. It is thus essential to clarify the doubts and confusion in the minds of physicians and people at large. This article is designed to reflect the best information regarding the Zika virus in depth. Background Zika virus (ZIKV) belongs to the family flavivirus is a mosquito-transmitted found in both Africa and Asia. Infection of this to human may result in a febrile illness similar to dengue fever and many other tropical infections found in these regions. World Health Organization (WHO) report that some neurological disorder such as Guillain Barre syndrome (GBS) and of microcephaly also caused by Zika virus infection. II. METHODS AND MATERIAL Epidemiology In 1947, Zika virus first found in rhesus monkeys in the Zika forest of Uganda.[2] It was later identified in humans in 1968 for the first time in Nigeria. There were only about 14 or 15 cases documented until 2007. In 2007, sudden spontaneous occurrence of Zika was reported, in the Island[3]. Currently Zika virus has spread to other countries in America, Brazil, and the Colombia.WHO has reported 23 countries and territories in Americas from where local transmission of Zika virus has been reported.[4]. Out Of 76-suspected deaths from microcephaly and congenital central nervous system malformations, 15 were investigated and confirmed to have microcephaly and/or central nervous system malformations. Structure of the Zika virus Zika virus, has a positive-sense, single-stranded RNA genome approximately 11 kilobases in length. The RNA contains strands of 5′ and 3′ that encodes a polyprotein and was cleaved into three structural proteins, namely a) the capsid (C), b) premembrane/membrane (perm), and c) envelope (E), and seven non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, 2K, NS4B, and NS5) [5].