IJSRST1841138 | Received : 15 Jan 2018 | Accepted : 02 Feb 2018 | January-February-2018 [ (4) 2: 587-582] © 2018 IJSRST | Volume 4 | Issue 2 | Print ISSN: 2395-6011 | Online ISSN: 2395-602X Themed Section: Science and Technology 587 Synthesis, Characterization and Evaluation of Biological Properties of Transition Metal Chelates with Schiff base Ligands Derived from Glutaraldehyde with L-Leucine S. Ajith Sinthuja, Y. Christabel Shaji , G. Leema Rose Department of Chemistry, Holy Cross College (Autonomous), Nagercoil, Tamil Nadu, India ABSTRACT A nitrogen-oxygen Schiff base HL derived from Glutaraldehyde and L-Leucine has been reacted with different divalent metal ions in 2:1 molar ratio, producing neutral complexes . All compounds were characterized using physico-chemical and spectroscopic methods namely elemental analysis, melting point, magnetic moment measurement, conductivity measurement, UV-Vis, IR, 1 HNMR spectroscopy and XRD measurements. They were further analysed by thermal technique (TGA/DTA) to gain better insight about the thermal stability and kinetic properties of the complexes. The IR data demonstrated the tetradentate binding of Schiff base ligand. The molar conductivity values were relatively low , showing their nonelectrolytic nature. Room temperature magnetic susceptibility measurements revealed that the nature of Ni(II) and Cu(II) complexes were paramagnetic. The in vitro antimicrobial activities of all the compounds were screened against different microbial species by Disc Diffusion method and showed better activity compared to parent drug and control drug. Keywords: Schiff base, Metal complexes, IR, XRD, Antimicrobial activity I. INTRODUCTION Transition metal complexes derived from Schiff bases have occupied a central role in the development of coordination chemistry. Schiff base can accommodate different metal centers involving various coordination modes thereby allowing successful synthesis of homo and hetero metallic complexes with varied stereochemistry .This feature is employed for modeling active sites in biological systems. A large number of Schiff bases and their complexes have been investigated for their interesting and important properties, such as their ability to reversibly bind oxygen, their catalytic activity in the hydrogenation of olefins, their photochromic properties and their complexing ability towards some toxic metals. Many biologically important Schiff bases have been reported in the literature possessing, antimicrobial, antibacterial, antifungal, anti-inflammatory, anti convulsant, antitumor and anti- HIV activities (1-4) . In vivo studies have indicated that some biologically active compounds may become more carcinostatic and bacteriostatic upon chelation (5) . Several reviews showed that the metallo-organic chemistry of such compounds greatly influence their biological action highlighting the catalytic function metal in many biological processes (6-8) . Therefore, considering the above facts and continuing our interest in this field, the present work reports a study on the synthesis, characterization and antimicrobial properties of Ni and Cu complexes with the Schiff base derived from Glutaraldehyde and L- Leucine (HL). II. EXPERIMENTAL Materials and Physical Measurements: All the glassware used for the preparation were cleaned with chromic mixture ,distilled water and then dried in Oven at 110 o C. All the chemicals such as Glutaraldehyde, L- Leucine, Cupric nitrate and Nickel