WORLD SCIENCE ISSN 2413-1032 26 № 7(35), Vol.4, July 2018 http://ws-conference.com/ dzǟDzǻǪǨǵǵȇ ǯǨǫǶǹǺǸǭǵȄ ǟǵǼǭDzǾǟǠ ǹǭǿǶǪǰǪǟǬǵǰǽ ȀdzȇǽǟǪ Ǫ ǨǴǩǻdzǨǺǶǸǵǰǽ ǻǴǶǪǨǽ Ɍɢɬɨɜɚ Ɍ. А., ɞ.ɦɟɞ.ɧ., ɞɨɰɟɧɬ, ɤɚɮɟɞɪɢ ɫɿɦɟɣɧɨʀ ɦɟɞɢɰɢɧɢ ɬɚ ɚɦɛɭɥɚɬɨɪɧɨ-ɩɨɥɿɤɥɿɧɿɱɧɨʀ ɞɨɩɨɦɨɝɢ ɇɚɰɿɨɧɚɥɶɧɚ ɦɟɞɢɱɧɚ ɚɤɚɞɟɦɿя ɩɿɫɥяɞɢɩɥɨɦɧɨʀ ɨɫɜɿɬɢ ɿɦɟɧɿ Ʌ. ɉ. Шɭɩɢɤɚ Ɇɚɬɸɯɚ Ʌ. Ɏ., ɞ.ɦɟɞ.ɧ., ɩɪɨɮɟɫɨɪ, ɡɚɜ. ɤɚɮɟɞɪɢ ɫɿɦɟɣɧɨʀ ɦɟɞɢɰɢɧɢ ɬɚ ɚɦɛɭɥɚɬɨɪɧɨ-ɩɨɥɿɤɥɿɧɿɱɧɨʀ ɞɨɩɨɦɨɝɢ ɇɚɰɿɨɧɚɥɶɧɚ ɦɟɞɢɱɧɚ ɚɤɚɞɟɦɿя ɩɿɫɥяɞɢɩɥɨɦɧɨʀ ɨɫɜɿɬɢ ɿɦɟɧɿ Ʌ. ɉ. Шɭɩɢɤɚ ɍɤɪɚʀɧɚ. ɦ. Ʉɢʀɜ. ɇɚɰɿɨɧɚɥɶɧɚ ɦɟɞɢɱɧɚ ɚɤɚɞɟɦɿя ɩɿɫɥяɞɢɩɥɨɦɧɨʀ ɨɫɜɿɬɢ ɿɦɟɧɿ Ʌ. ɉ. Шɭɩɢɤɚ. Ʉɚɮɟɞɪɚ ɫɿɦɟɣɧɨʀ ɦɟɞɢɰɢɧɢ ɬɚ ɚɦɛɭɥɚɬɨɪɧɨ-ɩɨɥɿɤɥɿɧɿɱɧɨʀ ɞɨɩɨɦɨɝɢ. DOI: https://doi.org/10.31435/rsglobal_ws/12072018/6025 ARTICLE INFO Received: 06 May 2018 Accepted: 19 June 2018 Published: 12 July 2018 ABSTRACT Objective. A comparative study was aimed at the study of the effectiveness and evaluation of the dynamics of clinical and laboratory parameters of therapy with oral antimicrobial Flaprox versus nitrofuran therapy in patients with exacerbation of chronic urinary tract infection in outpatient settings. Object and methods of research. ɌСО ЬЭЮНв ТЧМХЮНОН 40 ЩКЭТОЧЭЬ (16 men, 24 women) with exacerbation of chronic pyelonephritis. Participants in the study were divided into 2 groups: 26 patients who received Flaprox 500 mg twice a day for 10 days in the main group (A), 14 patients in the control group (B) received nitrofuran 100 mg 4 once a НКв ПШЫ 10 НКвЬ. TСО ЦОКЧ КРО ШП ЭСО ЩКЭТОЧЭЬ аКЬ γ9.8 ± 8.9 вОКЫЬ Results. The regression of clinical manifestations of urinary tract infection in the study process was noted in both groups. In the main group, the dynamics of reduction of symptoms of general intoxication and normalization of local symptoms and inflammatory changes in blood and urine has a more pronounced tendency from 5 days of treatment and persisted throughout the course of therapy. Conclusions. The possibilities of optimization of antimicrobial therapy by general practitioners and family physicians in the management of patients with urinary tract infections in outpatient settings have been investigated. Flaprox useing for 10 days allowed to reliably reduce or eliminate dysuria, infection of the urinary tract (bacteriuria), and inflammatory process (leukocythria) without negative changes in the blood biochemistry analysis. Therapy of UTI with Flaprox demonstrates efficacy in comparison with the use of nitrofurans and the achievement of positive dynamics of clinical and laboratory parameters in a shorter time. KEYWORDS urinary tract infections; pyelonephritis; Flaprox; Escherichia coli; biofilms; leukocyturia; bacteriuria. Citation: Ɍɢɬɨɜɚ Ɍ. Ⱥ., Ɇɚɬɸɯɚ Ʌ. Ɏ. (2018) Likuvannia Zahostren Infektsii Sechovyvidnykh Shliakhiv v Ambulatornykh Umovakh. World Science. 7(35), Vol.4. doi: 10.31435/rsglobal_ws/12072018/6025 Copyright: © 2018 Ɍɢɬɨɜɚ Ɍ. А., Ɇɚɬɸɯɚ Ʌ. Ɏ. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Аɤɬɭɚɥɶɧɿɫɬɶ. ȱɧɮɟɤɰɿʀ ɫɟɱɨɜɢɜɿɞɧɢɯ ɲɥɹɯɿɜ (ȱɋɒ) є ɧɚɣɛɿɥɶɲ ɪɨɡɩɨɜɫɸɞɠɟɧɢɦɢ ɡɚɯɜɨɪɸɜɚɧɧɹɦɢ ɜ ɪɿɡɧɢɯ ɜɿɤɨɜɢɯ ɤɚɬɟɝɨɪɿɹɯ. ȼɨɧɢ ɩɨɫɿɞɚɸɬɶ ɩɟɪɲɟ ɦɿɫɰɟ ɡɚ ɱɚɫɬɨɬɨɸ ɫɟɪɟɞ ɜɫɿɯ ɧɟɮɪɨɥɨɝɿɱɧɢɯ ɡɚɯɜɨɪɸɜɚɧɶ ɬɚ ɨɞɧɟ ɡ ɩɪɨɜɿɞɧɢɯ ɦɿɫɰɶ ɫɟɪɟɞ ɿɧɮɟɤɰɿɣɧɨʀ ɩɚɬɨɥɨɝɿʀ ɥɸɞɢɧɢ. ɉɟɪɫɿɫɬɟɧɰɿɹ ɞɚɧɢɯ ɡɚɯɜɨɪɸɜɚɧɶ ɧɚ ɩɪɨɬɹɡɿ ɬɪɢɜɚɥɨɝɨ ɱɚɫɭ ɩɪɢɡɜɨɞɢɬɶ ɞɨ ɡɧɢɠɟɧɧɹ ɮɭɧɤɰɿʀ ɧɢɪɨɤ ɡɚ ɪɚɯɭɧɨɤ ɪɨɡɜɢɬɤɭ ɬɭɛɭɥɨɿɧɬɟɪɫɬɢɰɿɚɥɶɧɢɯ ɡɦɿɧ, ɩɨɪɭɲɟɧɧɹ ɭɪɨɞɢɧɚɦɢɤɢ, ɬɚ ɪɨɡɜɢɬɤɭ