IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 17, Issue 8 Ver. 8 (August. 2018), PP 42-45 www.iosrjournals.org DOI: 10.9790/0853-1708084245 www.iosrjournals.org 42 | Page Clinical and etiological profile of Chronic kidney disease patients on hemodialysis in a tertiary care hospital in northern part of Bangladesh ABM Mobasher Alam 1 , Syed Anissuzzaman 2 , Nusrat Jahan 3 , ** Md. Shakhawat Hossain 4 1. Associate Professor and Head of Nephrology, Rangpur Medical college Hospital, Bangladesh 2. Assistant Professor of Nephrology, Rangpur Medical college Hospital, Bangladesh 3. Assistant Professor of Paediatric hematology and oncology, Rangpur Medical college Hospital, Bangladesh 4. **.Assistant Registrar of gastroenterology, Rangpur Medical college Hospital, Bangladesh Corresponding Author: Md.Shakhawat Hossain Abstract: Background: Chronic Kidney Disease (CKD) is emerging as an important public health problem, not only in developed countries, but also in developing countries including Bangladesh.Objective: To study the clinical and etiological background of patients with CKD on maintenance hemodialysis Method: This cross sectional study was conducted in the Department of Nephrology, Rangpur Medical College Hospital a tertiary level hospital from January 2017 to December 2017 over a period of one year. Ninety six CKD patients above 18 years of age on renal dialysis, and willing to participate in the study were enrolled in this study. Those who did not give informed consent, or had severe cognitive, speech or hearing defect were excluded from this study. Results: In this study, majority of the patients were in age groups 40-59 years. Males () were predominant (59.4% vs 40.6%). Hypertensive nephropathy (60.4%), CGN (36.5%), diabetic nephropathy (24.0%) were the most common etiologies found in this study. Cigarette smoking was prevalent in 18.8%, tobacco chewing 14.6%, NSAID use in 5.2% and alcohol consumption in 1.0% cases. Majority of the patients had Oliguria (72.9%), followed by 61.5% had GI symptoms 40.6% had dyspnea, 38.5% had prurius, 28.1% had volume overload and 12.5% had neuromuscular. Mean hemoglobin was 8.55 ± 2.12g/dl varying within a range of 3.80 g/dl to 12.9 g/dl. Anemia was present in 90.6% and 15.6% had a hemoglobin less than 7g/dl.Conclusions: The most common etiologies of CKD are hypertensive nephropathy, CGN and diabetic nephropathy. Common manifestations are oliguria, GI symptoms, dyspnea and prurius. Smoking is one of the risk factors of CKD. Keywords: CKD, hemodialysis, etiology, manifestation. --------------------------------------------------------------------------------------------------------------------------------------- Date of Submission: 06-08-2018 Date Of Acceptance: 20-08-2018 --------------------------------------------------------------------------------------------------------------------------------------- I. Introduction Chronic Kidney Disease (CKD) is determined by the presence of kidney injury and by the level of renal function, assessed according to the glomerular filtration rate. CKD is divided into five stages. [1] Until the fourth stage of the disease, conservative treatment is recommended. End-Stage Renal Disease (ESRD), the most advanced stage, when the kidneys can no longer maintain homeostasis of the body, the patient will depend on dialysis or kidney transplant. [2] The cause of CKD is unclear in majority of cases, however renal biopsy could help to reach aetiology in most case. The cause of CKD depends on presence or absence of underlying systemic diseases and location of known or presumed pathologic abnormalities (glomerular, tubule-interstitial, vascular or cystic and congenital diseases). [1] The clinical course is typically a progressive loss of nephron function ultimately leading to end stage renal disease (ESRD) characterized by hypertension, anemia, renal bone disease, nutritional impairment, neuropathy, impaired quality of life and reduced life expectancy ultimately needing some form of renal replacement therapy. This puts a substantial burden on global health resources since all modalities of treatment are expensive. Chronic Kidney Disease (CKD) is emerging as an important public health problem, not only in developed countries, but also in developing countries. [3] Reasons for rising incidence of CKD are increasing incidence of diabetes and hypertension. [4,5] WHO has identified kidney diseases as 12th and 17 th major cause of death and disability worldwide, respectively. [6] This study was conducted to see the clinical and etiological profile of the CKD patients on hemodialysis.