IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 17, Issue 9 Ver. 3 (September. 2018), PP 59-62 www.iosrjournals.org DOI: 10.9790/0853-1709035962 www.iosrjournals.org 59 | Page Hyalinised Oncocytoma of Parotid Gland: A Case Report Dr. Ramanpreet Kaur, Dr.Mohanvir Kaur, Dr.Ira Moudgill, Dr R.K. Kundal, Dr. Amitoj Sandhu, Dr. Vibhor Garg Corresponding Author: Dr. Mohanvir Kaur Abstract: Oncocytoma or oxyphilic adenoma is defined since the classic works of Hamperl as a benign tumor exclusively composed of oxyphilic cells ; the large eosinophilic cuboidal to columnar cells with more than 60% of their cytoplasm occupied by mitochondria. Oncocytomas are 1-2% of salivary gland neoplasms, hyalinsed oncocytoma with calcification is still rare. We report a case of 60 year female with swelling at the submandibular area since 4 months which was progressively increasing, and was non tender .fine needle aspiration was not done. Subsequently a biopsy was received in the pathology department which was clinically suspected to be submandibular lymph node but on microscopy it was diagnosed as hyalinised oncocytoma of parotid gland. -------------------------------------------------------------------------------------------------------------------------------------- Date of Submission: 28-08-2018 Date of acceptance: 11-09-2018 --------------------------------------------------------------------------------------------------------------------------------------- I. Introduction Oncocytes are epithelial cells which appear as cells with abundant granular, eosinophilic cytoplasm, central pyknotic nucleus and ultrastructerly are crammed with numerous mitochondria of various sizes. Oncocytes are seen in various organs like salivary glands, thyroid, parathyroid, pituitary, nasal cavities, sinuses, ocular caruncle, lacrimal glands, buccal mucosa, eustachian tube, larynx, oesophagus and organs like liver pancreas and kidney. [1] Onocytes may be seen in normal glands or may be part of neoplastic process. Since oncocytes are capable of undergoing mitotic division, a superveining neoplastic change is possible. [2] The World Health Organisation (WHO) classification of Salivary Glands neoplasms recoginses three oncocytic entities: oncocytosis, oncocytoma, oncocytic carcinoma. [3] The parotid gland is the most commonly involved salivary gland, accounting for 78-84% of salivary glands oncocytomas. Oncocytomas occuring in submandibular glands and minor salivary gland has been reported but are relatively uncommon. [4] In one large series, 20% of patients had either a history of radiation or of long term occupational exposure. [5] Oncocytomas most often occur as asymptomatic, well circumscribed, solitary, painless masses usually measuring 3-4 cm but may reach upto 7 cm in diameter. Rarely they may present with pain and discomfort. They may also occur as multifocal or bilateral neoplasms. Grossly oncocytomas are solid, well circumscribed, tan to red brown, nodular or multinodular lesions. Fibrous encapsulation has been a criteria used to distinguish oncocytoma from oncocytic hyperplasia, although in some oncocytomas it may be minimal. [6] II. Case Report We present a case of 65 year female who came to surgery outpatient department with complaint of painless swelling on submandibular region since 4 months which was hard in consistency, increasing progressively and was non tender. Clinically it was diagnosed as submandibular lymph node and was excised and swelling was sent to our department for histopathological examination. On gross examination a creamish grey soft tissue piece measuring 3x2.5x1 cm was whole passed. On microscopic examination: multiple sections studied from the received tissue show fibrous capsule. underneath seen are lobules of irregular sizes and shape having large cells with uniform nucleus and clear to eosinophilic granular cytoplasm. The lobules are seprated by thick hyalinised stroma having blood vessels along with areas of calcification.