1 Ethical issues in genomic research: proposing guiding principles co-produced with stakeholders D. Carrieri 1 , L. Jackson 2 , C. Bewshea 3 , B Prainsack 4 , J. Mansfield 5 , T. Ahmad 3 , N. Hawkins 6 , S. Kelly 1 1 Egenis, The Centre for the Study of Life Sciences, University of Exeter, UK 2 School of Medicine, University of Exeter, UK 3 IBD and Pharmacogenetics Research Group, Royal Devon & Exeter NHS Foundation Trust, Exeter, UK 4 Department for Political Science, University of Vienna, Austria & Global Health and Social Medicine, King’s College London, UK 5 Institute of Genetic Medicine, Newcastle University, UK 6 School of Law, University of Exeter, UK Abstract Ethical guidance for genomic research is increasingly sought and perceived to be necessary. Although there are pressing ethical issues in genomic research – concerning for example the recruitment of patients/participants; the process of taking consent; data sharing; and returning results to patients/participants – there is still limited useful guidance available for researchers/clinicians or for the research ethics committees who review such projects. This report outlines the ethical principles and guidance for genomic research co-produced with stakeholders during two workshops which took place in the UK between November 2016 and May 2017. The stakeholders involved in these workshops included: healthcare professionals, genomic research teams, academics, patients, biobank managers, and representatives from the Health Research Authority (HRA), NHS Research Ethics Committees, patient support groups, pharmaceutical industry, and health policy think tanks. The co-produced principles and guidance are specifically aimed at researchers/clinicians and members of NHS Research Ethics Committees, and are formulated with the intention to be clear and accessible, both in terms of content and language, to these groups.