International Journal of Biomedical And Advance Research ISSN: 2229-3809 (Online) Journal DOI:10.7439/ijbar CODEN:IJBABN IJBAR (2014) 05 (10) www.ssjournals.com Research Article Effect of aging on various haematological parameters Maulik S. Padalia 1 , R. S. Trivedi 2* , Pankaj Panchal 1 , Hitesh Jani 1 1 Department of Physiology, M. P. Shah Government Medical College, Jamnagar, India 2 Department of Physiology, P. D. U. Government Medical College, Rajkot, Gujarat, India *Correspondence Info: Dr. R. S. Trivedi Associate Professor, Department of Physiology, P. D. U. Government Medical College, Rajkot, Gujarat, India E-mail: drrstrivedi@yahoo.com 1. Introduction Aging is the progressive deteriorative changes during the adult period of life which underlie an increasing vulnerability to challenges and thereby decrease the ability of the organism to survive. 1 According to different studies 2,3,4,5 the hemoglobin concentration, red blood cell count and hematocrit value began to decrease in men in their sixth decade and in women in their seventh decade and the change were more prominent with advancing age, especially in men. The present study was carried out to find the significant changes in various haematological parameters with advancing age both in males and females. 2. Materials and methods The prospective cross sectional study was conducted in the Physiology Department in collaboration with Pathology Department at M.P Shah Govt Medical College, Jamnagar, Gujarat. The study duration was of six months and sample size was 103. Healthy volunteers in age group of 20 to 89 years were included in our study. Both male and female volunteers were included. Out of these, 53 were males and 50 were females. The instrument used in this study was automated cell counter, named Sysmex KX-21. The Sysmex KX-21 is an automatic multi- parameter blood cell counters for in vitro diagnostic use in clinical laboratories. 6 2.1 Statistical analysis The appropriate statistical method ANOVA was employed. The probability value p < 0.05 considered as statistically significant and probability value p > 0.05 considered as statistically non significant. 3. Results Table - 1 show mean values of Haemoglobin, RBC count and Packed cell volume (PCV) among females in all age groups. The difference among females in all the age group was found to be statistically non- significant (p > 0.05). Table -1: Hemoglobin, RBC Count and PCV among Females Age group(in years) Hemoglobin (gm %) Mean + SD RBC Count (million/cumm) Mean + SD Packed Cell Volume (%) Mean + SD 20-29 12.24 + 0.65 4.54 + 0.60 36.54 ±1.13 30-39 12.40 ± 0.93 4.41 ± 0.24 36.17 ± 1.94 40-49 12.41 ± 1.60 4.63 ± 0.58 36.95 ± 4.51 50-59 12.10 ± 1.06 4.38 ± 0.80 36.47 ± 3.24 60-69 11.41 ± 0.53 4.37 ± 0.52 34.74 ± 2.62 70-79 11.74 ± 1.94 4.34 ± 0.90 36.07 ± 5.19 80-89 11.60 ± 0.65 4.34 ± 0.53 34.46 ± 2.03 Table - 2 shows mean values of Haemoglobin, RBC count and Packed cell volume (PCV) among males in all age groups. The difference among males in all the age group was found to be statistically significant (p < 0.05). The difference among males was highly significant in fifth decades. Abstract Background: The present study was done to find out the significant changes in various haematological parameters with advancing age, both in males and females. Material and methods: The prospective cross sectional study was conducted in the Physiology Department in collaboration with Pathology Department at M.P Shah Govt Medical College, Jamnagar, Gujarat with sample size of 103 in the age group of 20 to 89 years. Out of these, 53 were males and 50 were females. Haematological parameters were measured by automated cell counter. Result: Our result showed that most of the haematological parameters decrease significantly in males after fifth decades. In females, the changes were not significant in most of the haematological parameters. Conclusion: Non significant changes of haematological parameters in females might have some hormonal correlation. Poor nutrition resulting in vitamin B 12 and folic acid deficiency in old age might be the cause of early haematologial changes and early aging. Further study with large sample size may reveal more information. Keywords: Haematological parameters, aging