Panchal Upasana et al/ International Journal of Biomedical and Advance Research 2015; 6(06): 470-474. 470 IJBAR (2015) 6 (06) www.ssjournals.com International Journal of Biomedical and Advance Research ISSN: 2229-3809 (Online); 2455-0558 (Print) Journal DOI: 10.7439/ijbar CODEN: IJBABN Original Research Article A cytological and histological comparative study of salivary gland lesions at tertiary health care centre Panchal Upasana * , Shah Ina and Goswami Hansa Department of Pathology, BJ Medical College, Gujarat University, Ahmedabad, Gujarat, India *Correspondence Info: Dr. Upasana Panchal Final year postgraduate student Department of pathology, BJ Medical College, Gujarat University, Ahmedabad-380011, India E-mail: drupasanapanchal@gmail.com Abstract Aim/Objective: The objective of this study was to evaluate the diagnostic accuracy of FNAC in various salivary gland lesions and it’s correlation with histopathology, which helps in the appropriate management of the patient. Materials and Methods: A total of 120 FNA were performed on salivary gland lesion from September 2013 to October2014 at department of pathology in tertiary health care centre. Surgically resected, formalin fixed specimen were received, they were processed and slides were prepared. The cytological and histopathological stained slides were studied, analysed and correlated clinically. Results: The cytological features of 120 cases were studied and following lesions were observed in FNAC study of 120 cases: Pleomorphic adenoma were in 76, chronic sialadenitis in 16, Warthin’s tumour in 4, Cystic lesion in 5, Mucoepidermoid carcinoma in 6, Acinic cell carcinoma in 3, Carcinoma EX pleomorphic adenoma in 3, metastatic deposits in 2, benign parotid tumour in 2 and malignant tumour (unspecified) in2, Neuroblastoma in 1. Out of 120 cases histopathologies of 87 cases were available and out of which 75 cases were correlated in both cytology and histology. The sensitivity, specificity and diagnostic accuracy, positive predictive value, negative predictive value of present study is 89.29%, 91.67%, 86.21%, 96.15% and 78.57% respectively. Conclusion: FNAC of the salivary gland is a safe and reliable technique in the primary diagnosis of salivary gland lesions. FNAC of the salivary gland tumours has a high diagnostic accuracy, though rate of characterization of specific type of tumor is lower, due to variable cytomorphology. In such cases, histopathological examination may prove to be accurate for diagnosis. This study documents that FNAC of the salivary gland tumours is accurate, simple, rapid and cost-effective for the patient. Keywords: salivary gland lesion, FNAC, sensitivity, specificity, diagnostic accuracy 1. Introduction Fine needle aspiration cytology (FNAC) is accurate, simple, and cost-effective for the patient. Salivary gland tumours are rare and they account for only 2-6.5% of all the head and neck tumours, their superficial location, easy accessibility and high diagnostic accuracy makes FNAC a popular method for evaluation. Among the entire salivary gland lesion, 64-80% occur in the parotid glands, 7-11% occur in the sub-mandibular, less than 1% occur in the sublingual and 9-23% occur in the minor salivary glands 9 . A review of the various recent studies shows that the diagnostic sensitivity of FNAC varied from 81-100%, that the specificity varied from 94-100% and that the diagnostic accuracy varied from 61- 80%[13-17]. Hence, FNAC proves to be simple and accurate method for diagnosis and thus appropriate therapeutic management could be planned earlier. Hence, the current study was done to know the diagnostic accuracy, sensitivity, specificity of FNAC in diagnosing salivary gland lesion which helps in appropriate therapeutic management. 2. Materials and Methods Informed consent was taken from patient, then swelling was palpated and fixed, under aseptic precautions, a 10 cc syringe with a 23 gauge needle was introduced into the nodule. The material was aspirated and smeared onto clean glass slides. The