J pub health catalog 2018 Volume 1 Issue 2 17 http://www.alliedacademies.org/public-health-nutrition/ Review Article Introduction Increased adequate amount consumption of fruits and vegetables is recommended in dietary guidelines worldwide and intake of fruits like berries are rich in vital nutrients and phyto-nutraceuticals can prevent various diseases and disorders and more Neurodegenerative disorders. Fruits and vegetables may have noticeable long-term physiological effects due to their metabolic bioactivity and also enhance remarkable effect in the laboratory and epidemiological studies have been associated with a variety of nutrient and non-nutrient constituents, being many of them characterized by their antioxidant properties [1-5]. Compounds like ascorbic acid, tocopherols, β-carotene and phenolic compounds, favonoids have high antioxidant capacity and promising potential against current therapeutic neuroproteins [6]. The colorful berries fruits such as blackberry (Rubus species), black raspberry (Rubus occidentalis), blueberry (Vaccinium corymbosum), cranberry (Vaccinium macrocarpon), red raspberry (Rubus idaeus), and strawberry (Fragaria ananassa) are remarkably good source countered to therapeutic neuro targets of neurological disorders. Researchers analyzed berry fruits extracts for most common abnormalities and obtained signifcant results and have suggested that consumption of colored fruits and vegetables are associated with reduced risk of human breast cancer [7,8], human melanoma cancer [9,10], human ovarian cancer, and also help in the prevention of Alzheimer’s disease [11-13]. The majority of the compounds examined to date with a direct relevance to the AD are primarily from plants, from animal, marine and microbial sources. The review focuses on the berries compounds that might underlie the purported benefcial improvements in memory and cognition, neurovascular function, and in neuro-protection. Occurrence and Season Berries are used worldwide since ancient times and still Nature has lots of fora-bearing fruits, vegetables with human beings. Berries contain a powerful source of natural antioxidants. Berries plays an essential role in prevention and therapy of various neurodegenerative diseases, like Alzheimer’s disease (AD), Parkinson’s disease and other neuronal dysfunctions as they are a diverse source of a large variety of nutritive, non- nutritive and bioactive compounds. Polyphenolic antioxidants present in different varieties of berries present in phyto-compounds which are present in nature may be used as a cure to delay neuro-degeneration, improvement of memory and cognitive function of frontal lobes. Berries such as Strawberry, Blueberry, Blackberry etc., have also confrmed neuroprotective effect against the AD. The molecular mechanism behind this therapeutic effect is the association of discrete signalling pathways by the work of phytonutrients which results in protein folding and neuro-infammation. In Alzheimer’s, the neuroprotective properties of the diversely occurring bioactive components of the berries have been used and tabulated in this review. Abstract Current Alzheimer’s management with berries fruits therapy. Rahul Singh* Department of Bioinformatics, Integral University, Uttar Pradesh, India Accepted on March 26, 2018 Keywords: Alzheimer’s disease, Antioxidant, Neurodegeneration, Wnt signalling, Flavonoids popular in Europe and North America today. The industries dealing with berry varies from country to country because of different cultivation and growth condition. Some berries such as raspberries and strawberries have been bred for hundreds of years and are distinct from their wild counterparts, while other berries, such as lingonberries and cloudberries, grow almost exclusively in the wild. Besides of their different growing season, they also differ in temperature and time duration. For example, many soft fruit berries require a period of temperatures between 0°C and 10°C for breaking dormancy. Generally, strawberries require 200-300 hours, blueberries 650- 850 hours, blackberries 700 hours, raspberries 800-1700 hours, currants and gooseberries 800-1500 hours, and cranberries 2000 hours [14]. Moreover, temperature regimes also severely affect growth and productivity of berries. The tolerable temperatures range from -29°C to -31°C, depending on variety [14]. Major Classes of Berries The word “berry” meets the true botanical nomenclature as a fruit. For example Wild rose, Grapes, Elderberry, Currant, Barberry, Rosehips, Gooseberry etc. are true berry. "Stone fruits" is a drupe berry fruit with a feshy fruit having a small stone. Acai, Hackberry, Sugarberry, Persimmon, Barbados cherry, Acerola, Indian plum, West Indian cherry, Goji berries do not meet the botanical classifcation but come under the category of berries. The botanical classifcation is not met by a few Epignyous types. Lingonberry, Cranberry, Bearberry, Crowberry, Blueberry, Bilberry, Juniper berries, Cowberry, Foxberry, Mountain cranberry, Red chokeberry, Black chokeberry, Purple chokeberry, etc. are the example of epignyous fruits. Rasberry, Strawberry, Blackberry, Dewberry, Salmonberry, Bayberry, Boysenberry, Mulberry, Cloudberry, Chehalm Berry, Loganberry, Thimbleberry, Wineberry, Youngberry, Juneberries etc contain multiple fruit seeds which are present in compound fruits.