Chemical Science Review and Letters ISSN 2278-6783 Chem Sci Rev Lett 2017, 6(21), 435-438 Article CS142048023 435 Research Article Effect of Pre-Biotic and Pro-Biotic Dietary Supplementation in Growing Pigs D. Maheswara Reddy 1 *, G. Vijaya Bhaskar Reddy 1 , and S. Vani 2 1 Department of Livestock Products Technology, CVSc, Proddatur, SVVU, INDIA 2 Department of Animal Genetics & Breeding, CVSc, Proddatur, SVVU, INDIA Introduction Now a days the use of antibiotics as growth promoters were banned due to development of bacterial antibiotic resistance. In addition, misusing antibiotics as feed additives for pig production can result in high antibiotic residues in pork. Developing new feeding strategies like pre and pro-biotics are particularly important in reducing post weaning digestive disorders. In pig production, pro-biotics, which are live cultures of harmless bacteria or yeast species that equilibrate intestinal microflora, maintaining the intestinal ecosystem, improving animal health, improving growth rate, feed efficiency, barrier properties of the intestinal wall, immunity and nutrient digestibility by increasing the gastrointestinal population of beneficial bacteria. Pre-biotics like Fruto-oligosaccharides (FOS) are water soluble carbohydrates which can be classified as non-digestible oligosaccharides and cannot be hydrolyzed by the enzymes of endogenous origin (Oku et al., [1]. As a consequence these are available as a substrate for the gastro- intestinal microflora. Several authors reported increased growth and feed conversion efficiency together with reduced incidence of diarrhoea on feeding FOS in young pigs. Hence the present research was designed to investigate the effect of feeding FOS and pro-biotic on the growth performance of growing crossbred pigs. Materials and Methods The basal diet formulated (NRC, [2] was fed to 28 male pigs (75% LWY X 25%desi) with an average body weight of 20±0.5 Kg, divided into four groups at random. All the pigs were dewormed before the start of the grower phase (20- 40 kg) and housed individually in separate pens. Feed was offered according to the groups. The daily feed offered, the left over feed, faeces voided were recorded and the body weights of the pigs were recorded at weekly intervals. Fresh faecal samples of 1-2g were taken at every fort-nightly intervals from the rectum under sterile conditions for bacteriological enumeration. One digestion trial was conducted after the animals attained a body weight of about 30 kg using all the 7 animals in each treatment. The diet and faecal samples were analyzed for proximate composition (AOAC, [3]. The data thus obtained was subjected to statistical analysis using SPSS MAC, version 20.0, SPSS Chicago (US). Abstract Twenty eight crossbred LWY growing pigs weighing 20±0.5 kg were divided into 4 groups to study the effect of Pre-biotic (Fructo- oligosaccharides) and Pro-biotic (Scchyromyces cerevisiae, a dry yeast) on nutrient utilization, performance and faecal bacterial populations. Group one (T1) is the control without any feed additive, T2 is the T1+ 2% Pre-biotic, T3 is the T1+ 0.2% Pro-biotic and T4 is the T1 with 2% Pre- biotic and 0.2% Pro-biotic. Organic matter, crude fibre, crude protein digestibility values and average daily gain were higher (P<0.05) for T4. Total number of days taken to reach the target weight (40 kg) and feed conversion ratio were less (P<0.05) for T4. Total count, Coliforms, Salmonella and Staphylococcus bacteria was decreased with a corresponding increase (P<0.05) in Lactobacillus counts in T4 followed by T3, T2 and T1 (control). It was concluded that Pre-biotic in combination with pro-biotic supplement provide better in terms of performance, growth rate and decreases the pathogenic bacteria. Keywords: Pre-biotic, Pro-biotic, pigs, growth performance, nutrient utilization, faecal microflora *Correspondence Author: Maheswara Reddy Email: drmaheshlpt@gmail.com