Open Access Journal Indian Journal of Medical Research and Pharmaceutical Sciences November 2018;5(11) ISSN: ISSN: 2349-5340 DOI: 10.5281/zenodo.1684576 Impact Factor: 4.054 ©Indian JMedResPharmSci http://www.ijmprs.com/ [16] EVALUATION OF HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITIES OF METHANOLIC EXTRACT OF ANTIDESMA BUNIUS (LINN.) (FAMILY EUPHORBIACEAE) LEAF Md. Shariful Islam* 1 , Mst. Shirajum Munira 1 , Sabiha Ferdowsy Koly 1 , Md. Sharif Ahammed 1 & Dr. Saikat Saha 2 1 Department of Pharmacy, Southeast University, Dhaka, Bangladesh 2 Consultant neurosurgeon, Gouri Devi Hospital and Research Institute Durgapur, MBBS, MS, General surgery, MCH neurosurgery from PGI Chandigarah, India. Abstract Keywords: Antidiabetic, Methanolic extract, Antidesma bunius, Alloxan, Hypolipidemic activity, Hypoglycemic activity. Background and Objective: To evaluate hypoglycemic and hypolipidemic activities of methanolic extract of Antidesma bunius L. leaf. Methods: Diabetes was induced in male Long Evan rats by the administration of single intra-peritoneal injection of alloxan monohydrate (150 mg/kg b.w.). Effect of oral administration of two different doses of methanolic extract (250 and 500 mg/kg b.w.), metformin (100 mg/kg b.w.) alone for 7 days were examined on 0th, 3 th , 5 th and 7 th day of treatment to evaluate hypoglycemic and hypolipidemic activity. After 7 days of treatment, hypolipidemic effects were estimated by measuring serum biochemical parameters such as TC, TG, LDL and HDL. The survival rate, body weight and organ weight were also measured. Results: The leaves extract showed remarkable anti-diabetic property which was evaluated by the percentage of inhibition of the blood glucose level along with TG, TC, LDL and increase in HDL in high concentration of the plant extract compared to the metformin, a reference drug. Conclusion: It can be concluded that methanolic extract of A. bunius leaves possesses good hypoglycemic, hypolipidemic activity. Introduction Antidesma bunius (Family- Euphorbiaceae) is traditionally used as sudorific and in the treatment of snakebite, decoction is used to promote perspiration in fibrile condition, juice of the plant is useful in the treatment of insomnia. Fresh juice of the fruits is used in the manufacturing of wine as an antioxidant. Roots and leaf are antihelminthic and also used in indigestion cough and stomachache. The seeds are used against round worms and threadworms, coughs, flatulence, intestinal colic and also used as pesticide [1]. Diabetes mellitus (DM), commonly mention to as diabetes, is a group of metabolic disorders of carbohydrate, protein and fat results in high blood sugar levels over a prolonged period of time (World Health Organization, 2014) [2]. Severe complicacy of DM results in diabetic ketoacidosis, nonketotic hyperosmolar hyperglycemic coma, or death [3]. Chronic or Serious long-term complicacy of DM involve kidney disease, stroke, cardiovascular disease, foot ulcers, and destruction to the eyes [4]. In 2015, approximately 415 million people affected by diabetes worldwide [5], among them type 2 DM making up about 90% of the cases [6-7]. This study also suggests that 8.3% of the adult population affected by Type 1 DM, with equal rates in both women and men [8]. Laterally, the prevalence of type 1 DM is also continuously increasing to that of type 2 DM worldwide [9-11]. The amount of diabetic people in world is anticipated to increase to 366 million in 2030 [12]. Circumscribe almost 80% of the population associated with DM in under-developed and developing countries people [13]. Search out for new antidiabetic drugs with minimum or no side effects from