OPEN ACCESS Jacobs Journal of Agriculture Effects of Amprolium (Anticoccidial) on Some Productive and Reproductive Parameters of Rabbit Doe (Oryctolagus cuniculus) Ferdinand Ngoula *1 , GR Kagou Ndonfack 1 , A Kenfack 1 , MM Momo Chongsi 1 , VH Goumtsop 1 A Téguia 1 , P Kamtchouing 2 , J Tchoumboué 1 1 University of Dschang, Faculty of Agronomy and Agricultural Sciences, Department of animal Science, Dschang, Cameroon 2 University of Yaounde I, Faculty of Sciences, Department of Animal Biology and Physiology, Yaounde, Cameroon *Corresponding author: Dr. Ferdinand Ngoula, University of Dschang, Faculty of Agronomy and Agricultural Sciences, Department of animal Science, Laboratory of Animal Physiology, PO Box: 188 Dschang, Cameroon, Tel: +237 675125443; Email: fngoula@yahoo.fr Received: 05-02-2015 Accepted: 08-01-2015 Published: 08-14-2015 Copyright: © 2015 Ferdinand Research Article Cite this article: Ngoula F. Effects of Amprolium (Anticoccidial) on Some Productive and Reproductive Parameters of Rabbit Doe (Oryctolagus cuniculus). J J Agriculture. 2015, 1(1): 003. Abstract This study was designed to study the effects of Amprolium (anticoccidial drug) on some productive and reproductive parameters in female rabbit. For this purpose, 24 nulliparous local breed rabbits, aged 7 months on average were divided into four groups of 6 animals each, and randomized into 24 cages. Amprolium was administered at doses of 0.00, 0.20, 0.32 and 0.80 g/L of drinking water for 8 weeks (4 weeks before and after mating). The average Amprolium intake from the calculated water consumption was 0.00, 32.00, 69.00 and 136.00 mg/kg body weight. The main results showed that the pregnancy length of treated rabbits decreased with increasing doses of amprolium, with a significant difference (p<0.05) between the lowest (32 mg/kg) and the highest doses (136 mg/kg). The litter weight and milk production decreased signifi- cantly (p<0.05) in rabbits treated with 32 and 69 mg of Amprolium/kg compared to those of control group. Whatever the physiological stage, there was no treatment-related effects of Amprolium (p>0.05) on feed and water consumption, body weight gain, feed efficiency, average weight at birth, sex-ratio and viability of young rabbits in any of the study groups. These data demonstrated that Amprolium exerts an adverse effect on female fertility at all the considered doses. Keywords: Amprolium; Toxicity; Rabbit; Growth; Reproduction Introduction In developing countries, malnutrition is still relevant. Thus, animal proteins which have a very important place in the hu- man diet are difficult to access for most households [1]. The resolution of this problem remains a major concern and it is in this light that the different states encourage breeding by programs that firstly aim to improve breeding conditions and secondly to promote the emergence of new breeding sectors, especially the so-called non-conventional species including cane rat, Japanese quail, Gambian rat, snail and rabbit. Re- garding specifically the rabbit, this latter receives special at- tention for the quality of its white meat, its high prolificacy and its short production cycle [2]; its breeding can contrib- ute to the reduction of the abovementioned food deficit [3]. However, rabbit breeding faces several difficulties due to the lack of control in production methods and the fragility of the animal, especially in tropical regions where atmospheric conditions are favorable to the development of pathogens, making diseases the most redoubtable constraints [4];