OPEN ACCESS Jacobs Journal of Experimental Cardiology and Research Helicobacter pylori Infection is a Significant Risk Factor for Hyperhomocysteinemia in Patients with Coronary Artery Disease Soudabeh Falla *1,2 , Nariman Moradi 2 , Reza Fadaei 3 , Reza Ahmadi 2 , Azardokht Tabatabei 1 , Morteza Seif 4 1 Research center of Pediatric Infectious Disease, Rasool Akram Hospital, Iran University of Medical Sciences 2 Department of Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran 3 Department of Biochemistry, Tehran University of Medical Sciences, Tehran, Iran 4 Department of Medical Genetics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada. *Corresponding author: Dr. Soudabeh Fallah, Department of Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran., POBOX: 14155-5983, Tel: 021-86703115; Fax: +98 21 88058742; Email: fallah.s@iums.ac.ir Received: 12-17-2015 Accepted: 02-16-2016 Published: 04-29-2016 Copyright: © 2016 Soudabeh Falla Research article Cite this article: Soudabeh Falla. Helicobacter pylori Infection is a Significant Risk Factor for Hyperhomocysteinemia in Patients with Coronary Artery Disease. J J Exper Cardiol Res. 2016, 3(1): 016. Abstract Background The association between Helicobacter pylori infection and concentration of homocysteine is complicated in the pathogenesis of coronary artery disease. Aims We aimed to determine whether seropositivity to Helicobacter pylori infection is an independent risk factor for hyperhomo- cysteinemia patients with cardiovascular disease. Methods The H. pylori IgG, IgA and homocystein levels in 96 patients with cardiovascular disease and 64 participants free of cardio- vascular disease as control subjects were determined by ELISA assay. Results The results of present study showed that seropositivity to H. pylori IgG and IgA levels of CAD patients was significantly higher than controls and CAD patients with negative anti H. pylori IgG and IgA. A significant correlation was found between seropositivity to H. pylori IgG and homocysteine levels of CAD patients in comparison with controls and CAD patients with seronegativity to H. pylori IgG and IgA (r=0.233, P= 0.019). Conclusion The involvement of H. pylori infection in atherosclerosis process is based on the chronic inflammation which might facilitate the CAD-related pathologies. Moreover, effect of the presence of H. pylori infection on homocysteine levels elevation in CAD patients (as a risk factor independent of other traditional factors) was remarkable. Keywords: Cardiovascular disease; Helicobacter pylori; Homocysteine Abbreviations: CAD: Coronary Artery Disease; DM: Diabetes mellitus; HCY: Homocysteine;