International Journal of Pharmaceutical and Phytopharmacological Research (eIJPPR) | February 2018 | Volume 8 | Issue 1 | Page 75-80 Ni Wayan Bogoriani, The Activity of Bali Andong Rhizome Extract of Cordyline Terminalis Kunth as Hypolipidemia Agent in Wistar Rats with High- Cholesterol Diet ISSN (Online) 2249-6084 (Print) 2250-1029 www.eijppr.com The Activity of Bali Andong Rhizome Extract of Cordyline Terminalis Kunth as Hypolipidemia Agent in Wistar Rats with High-Cholesterol Diet Ni Wayan Bogoriani * , Ni Komang Ariati Department of Chemistry, Faculty of Mathemathic and Natural Science, University of Udayana, Indonesia. ABSTRACT Objective: Andong rhizome extract has inhibited the absorption of lipids in the intestine and was shown to decrease blood lipid profile levels in Wistar rats. This study was conducted to prove that intake containing saponins, can inhibit the absorption of lipids in the intestine, thus lowering blood plasma lipids in Wistar rats with high-cholesterol diet. Methods: The study has a randomized post-test design along with control group, using twenty-four male Wistar rats that were divided into four groups (six rats per group). Group I served as the control with standard diet. Group II, III, IV rats were given high-cholesterol diet. Group III and IV rats were treated with 30 mg/kg.b. w & 70 mg/kg.b. w of andong rhizome extract. After 28-day treatment, rats were fasted for 14 hrs, blood samples were taken and plasma was separated to evaluate the lipid profile. Results: The andong rhizome extract has shown a significant decrease (p<0.05) in plasma levels of total cholesterol, LDL cholesterol, triglycerides, VLDL, and the ratio of total cholesterol to HDL cholesterol and an increase in HDL cholesterol in groups III and IV compared to high-cholesterol group. Conclusion: Based on the results of this study, it can be concluded that intake of andong rhizome extract inhibited the absorption of lipids in the intestine, thus lowering blood plasma lipid of Wistar rats with a significant difference. Key Words: Andong Rhizome Extract, Ldl Cholesterol, Total Cholesterol, Diet High In Cholesterol, HDL Cholesterol, Cordyline Terminalis eIJPPR 2018; 8(1):75-80 HOW TO CITE THIS ARTICLE: Ni Wayan Bogoriani, Ni Komang Ariati. (2018). “The Activity of Bali Andong Rhizome Extract of Cordyline Terminalis Kunth as Hypolipidemia Agent in Wistar Rats with High-Cholesterol Diet”, International Journal of Pharmaceutical and Phytopharmacological Research, 8(1), pp.75-80. INTRODUCTION The effect of urbanization and modernization as well as the lack of sport activities have made most people change life style, including eating patterns. In terms of diet, people tend to choose things that are fast and instant without regard to side effects caused, so that it can lead to the emergence of various diseases, such as cancer, diabetes mellitus, hypertension, stroke, atherosclerosis, cataracts, and coronary heart disease[1, 2]. One of the causes of degenerative diseases is an excess of cholesterol in the body. Excessive levels of cholesterol in the body has caused health problems, incuding dyslipidemia and cardiovascular diseases [3, 4]. There was a positive correlation between increased concentrations of serum cholesterol and risk of coronary heart disease (CHD) [2, 4]. Heart disease was the leading cause of death in the United States [5]. Based on the results of research in animals and humans, it was showed that an increase in plasma cholesterol due to the intake of cholesterol, saturated fats, and trans fats, cause dyslipidemia [4-7]. Prevention of dyslipidemia and atherosclerosis was done by lowering cholesterol levels in the body by consuming natural medicine that can lower blood cholesterol levels to normal limits. Reduction in blood cholesterol can be done by lowering food intake, inhibiting the absorption of cholesterol, lower endogenous synthesis, as well as increasing spending bile and excreta [8-10]. Corresponding author: Ni Wayan Bogoriani Address Department of Chemistry, Faculty of Mathemathic and Natural Science, University of Udayana, Indonesia. E-mail:  bogi_wayan@yahoo.com Relevant conflicts of interest/financial disclosures: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest . Received: 28 October 2017; Revised: 22 January 2018; Accepted: 15 February 2018