*Corresponding author: Jyoti Sharma, Email: Jyoti311@gmail.com, Tel: 07512442769 Asian Journal of Nanoscience and Materials, 2018, 1(3), 135-141. One Pot synthesis of 2-substituted benzothiazoles catalyzed by Bi2O3 nanoparticles Jyoti Sharma*, Ravi Bansal, Pradeep K. Soni, Swati Singh and Anand. K. Halve School of studies in chemistry, Jiwaji University, Gwalior (M.P.) India-474011 Received: 28 March 2018, Revised: 05 May 2018 and Accepted: 09 May 2018. ABSTRACT: A convenient and efficient synthesis of the 2-substituted benzothiazole derivatives were carried out by the one-pot reaction of 2-aminothiophenol with various aromatic aldehydes in using Bi2O3 nanoparticles as a catalyst at 60 °C of the synthesized compounds were confirmed by FT- IR, 1 H NMR, 13 C NMR, Mass spectrometry and elemental analysis. This protocol revealed some advantages including, purification of the products by non-chromatographic method. Bi2O3 nanoparticles are cheap, readily available, versatile, environment friendly and recyclable. The reaction was carried out in ethanol, eliminating the hazardous organic solvents. KEYWORDS: One Pot, Benzothiazole derivatives, Synthesis, Bi2O3, Nano-particles and Catalyzed. GRAPHICAL ABSTRACT: 1. Introduction Heterocyclics have received considerable attention from the synthetic and medicinal chemistry community due to their widespread presence in the biologically and therapeutically active compounds [1-3]. Benzofused heteroatomic compounds having sulfur as heteroatom are broadly observed in natural products and used as drugs [4]. Various benzothiazole derivatives have been widely used due to their remarkable biological and pharmaceutical properties including, antifungal [5], antimicrobial [6,7], antitumor [8-12], anticonvulsant [13,14], antidiabetic [15], antiviral [16], anti-inflammatory [17,18], and enzyme inhibitory activity [19-21]. Thus, benzothiazole moiety is advantaged heterocyclic nucleus which has been used largely in medicinal chemistry, therefore much effort has been devoted to preparation of the benzothiazole derivatives. Over the years, many methodologies have been developed to synthesize the benzothiazole. Among all these methods, the most frequently used method is the condensation of 2-aminothiophenols with aldehydes. Generally, the catalysts used for this reaction are cyanide [22], copper(I) [23], chlorobenzene [24], yttrium chloride (YCl3) [25], tungstate sulfuric acid [26], molecular Iodine [27], Animal bone meal FULL PAPER