Difuse Dermal Angiomatosis of the Breast: Two Case Reports and Literature Review Navarro B 1* , Martin AB 1 , Aravena CDP 2 , Sanchez GJ 3 , Díaz MM 4 and Albi M 1 1 Gynecology and Obstetrics Department, Fundación Jimenez Díaz Hospital, Spain 2 Dermatology Department, Fundación Jimenez Díaz Hospital, Spain 3 Pathology Anatomy Department, Fundación Jimenez Díaz Hospital, Spain 4 General Surgery Department, Fundación Jimenez Díaz Hospital, Spain * Corresponding author: Navarro B, Fundación Jimenez Díaz Hospital, Avenida Reyes Católicos number 2, Ma- drid, Spain, Tel: +34680954190, E-mail: bea_0904@hotmail.com Citation: Navarro B, Martin AB, Aravena CDP, Sanchez GJ, Díaz MM, et al. (2018) Difuse Dermal Angiomatosis of the Breast: Two Case Reports and Literature Review. J Gynecol Women Healthcare 1: 201 Abstract CASE REPORT Open Access Volume 1 | Issue 2 ScholArena | www.scholarena.com Journal of Gynecology and Women Healthcare Objective: Difuse angiomatosis is characterized by difuse proliferation of benign endothelial cells in the dermis. Although it was previously believed that the lower limbs were the most frequent site of presentation, it now seems that the disease occurs most commonly in the breast. A number of treatment approaches have been used, although none appears to be efective in managing this condition. Case 1 Introduction Difuse dermal angiomatosis of the breast, a type of reactive angioendotheliomatosis, is a rare condition, and one that appears to be most frequently located in the breast rather than the lower limbs [1]. Clinical presentation involves poorly circumscribed plaques or ulceration of the breasts without associated scarring, and painful lesions with prominent vessels surrounding them [2-4]. Te number of lesions can range from a few to many. Several predisposing factors have been described, though the most important are large, pendulous breasts and smoking habit. Case report: We present two cases of difuse dermal angiomatosis of the breast in middle-aged, smokers women who had large, pendulous breasts. Defnitive treatment used in the two cases presented here were both smoking cessation and surgery. Conclusion: Findings suggest that smoking cessation and surgical management brings about the most favorable results, although further studies are required to confrm this hypothesis. Keywords: Breast; Reactive angioendotheliomatosis; Smoking habit ISSN: 2639-7285 A 61-year-old woman with a relevant past history consisting of obesity (BMI: 37), dyslipidemia treated with simvastatin, and depression treated with fuoxetine and lorazepam. Relevant gynecologic and obstetric history included a previous Cesarean section. She reported no alcohol intake, although she smoked 10 cigarettes a day. One year prior, the patient began to manifest telangiectatic vascular proliferation in the lef breast covering an area of 5 cm in diameter in the superomedial area, which developed ulceration and bleeding. In the 4 to 5 months afer this ulceration and bleeding resolved, she developed the same lesions in the lef breast, which also ulcerated on a number of occasions. Both breasts were abnormally large in size (Figure 1). Case Reports A skin biopsy was performed of the afected area, revealing reactive vascular proliferation in the dermis. Immunohistochemistry for estrogen receptors, HHV8, WT1, and C-myc was negative in whole samples (Figure 2,3 and 4). Terefore, in light of the patient’s medical history, physical examination of both breasts, and the fndings of the skin biopsy, a diagnosis of difuse dermal angiomatosis of the breast was reached. We screened for presence of an occult malignancy by carrying out chest radiography, abdominal ultrasonography, tests for tumor markers, and mammography and ultrasound scan of both breasts, all of which produced negative results. In order to rule out veno-