IOSR Journal Of Pharmacy www.iosrphr.org (e)-ISSN: 2250-3013, (p)-ISSN: 2319-4219 Volume 9, Issue 1 Version. I (January 2019), PP. 21-29 21 Formulation, Development and Evaluation of Mouth Dissolving Tablet Containing Cyclodextrin as Taste Masker Swati L. Khedekar 1 , Subhash V. Deshmane 1 (Asst. Professor) 2 ( Assit. Professor) Corresponding Author:Swati L. Khedekar Abstract: Mouth dissolving dosage form is very important for geriatric patients who have difficulty in swallowing tablets or in situation where access of water is not possible. The present study was carried out to prepare Telmisartan mouth dissolving tablet that can used as an antihypertensive drug. To mask the bitter taste of the drug, the drug-polymer complex (DPC) were prepared in various ratio(1:1, 1:2, 1:3, 1:4, 1:5 & 1:6) by solvent evaporation method and the characterization of DPCs were carried out by determining Drug content , in- vitro evaluation of drug complex & Threshold value determination. The threshold value was determined at 200μg/ml and the DPC was selected which masked the taste of drug was 1:3 ratio. Selection of superdisintegrants like crosspovidone, sodium starch glycolate, crosscarmellose sodium was carried out. Tablets were prepared along with other additives by direct compression method was used for preparation of mouth dissolving tablets. Tablets were evaluated for various tests like weight variation, hardness, friability, content uniformity, wetting time, water absorption ratio, in-vitro disintegration time, in-vitro dispersion time & dissolution. Keywords:Antihypertensive, Bitter Taste, , Superdisintegrants, Telmisartan, Threshold Value --------------------------------------------------------------------------------------------------------------------------------------- Date of Submission: 26-12-2018 Date of acceptance: 11-01-2019 --------------------------------------------------------------------------------------------------------------------------------------- I. INTRODUCTION Mouth dissolving table“The mouth dissolving tablets are defined as the solid dosage forms that rapidly get disintegrate and dissolve into saliva in the oral cavity, results into solution without the need of water for administration”. Oral administration is the most popular route for systemic effects due to its ease of ingestion, pain, avoidance, versatility and most importantly, patient compliance. Many patients have difficulty swallowing (dysphagia) tablets and consequently do not take medications as prescribed. The difficulty experienced in particular by pediatrics and geriatrics patients, but this also applies to the patients who are ill in bed or travelling. Other groups that may experience problems using conventional oral dosage form include the mentally ill, developmentally disable and patients who are uncooperative. It is estimated that 50% of the population is affected by this problem, which results in a high incidence of noncompliance and ineffective therapy. For this reasons, tablets that can dissolve or disintegrate in oral cavity, have attracted a great deal of attention. Indeed, the mouth dissolving tablet is an important and attractive alternative to liquid dosage form. Mouth dissolving tablets are not only indicated for people having difficulty in swallowing but also ideal for unfavorable conditions of administration where water is not available. Syrups are best for pediatrics but they are bulky and drugs are not as stable in liquid form as in solid form like tablets. Mouth dissolving tablets are also known as fast dissolving, rapid-dissolve, rapimelt, fast melts, porous tablets, EFVDAS or Effervescent Drug Absorption system, Orosolv, Zydis etc. II. ANALYTICAL METHODS 2.1 Determination of λ max 50 mg of Telmisartan was dissolved in 5 ml methanol and volume was made upto 50 ml by using distilled water. Filter the solution by using whatman filter paper and the wavelength was determined by using UV-visible double beam spectrophotometer (UV- 1601 SHIMADZU) in the range of 200-400 nm. 2.2 Standard calibration curve of Telmisartane in pH 6.8 phosphate buffer 2.2.1 Preparation of standard calibration curve Accurately weight 10 mg of Telmisartan was added in 10 ml volumetric flask and dissolve in sufficient quantity of methanol and lastly made the volume up to 10 ml using 6.8 phosphate buffer, take 1 ml from above