AL-Qadisiyah Journal of pure Science Vol.23 No.1Year 2018 242 Synthesis and Characterization of some N-arylhydrazone and Imides derivatives from nalidixic acid Received : 7/12/2017 Accepted : 18/1/2018 HalaShkyiar Lihimes 1 , HuthamAbd Ail Abd Al Hussain 2 Department of Chemistry, CollegeofScience, Babylon 1 University 2 kerbala University, College of veterinary. E-mail:huthamabd15@yahoo.com halashimery80@gmail.com Abstract: This research comprises the synthesizes of N-Arylhydrazone and Imides derivatives of Nalidixic acid were prepared by esterification of Nalidixic acid to form compound (1) then reacted with hydrazine hydrate 99% in ethanol to yield hydrazide derivative compound (2). The Schiff base (3a-3c) prepared from the corresponding aryl aldehydes with compound (2). Imides derivatives (4-6) were synthesized by reaction of compound (2) with appropriate anhydrides .The structures of compounds have been characterized by using some spectroscopic methods, 1 HNMR and FT-IR. Keywords: Nalidixic acid, Hydrazones, Imides Introduction: Nalidixic acid were quinolone first used in 1962 for treatment the infections of urinary tract in humans [1]. Nalidixic acid has been discovered by GeorgeLesher and coworkers as a byproduct in distillate during an attempt at chloroquine [2]. Nalidixic acid class of organic compounds (carboxylic acid ) with varied chemical and pharmacological applications [3] .such as antibacterial activity[4], antibiotic misuse [5], antimicrobial[6], antitumor[7], antimalarial [8], antiplatelet [9], antiulcer [10], antifungal agents [11] , antioxidant activity [12] , Also anumber of quinolone compounds are important as synthone in organic synthesis [13],and industrial importance [14]. Schiff bases have been exhibit biological activities, and important compounds groups in medicinal and pharmaceutical field [15]. Some azo compounds are well known to have antibacterial activity [16]. Materials and methods: Chemicals were obtained from Merck and BDH used without any further purification. The Melting points of chemicals were measured on GallenKamp ( MFB-600) melting point apparatus and are not corrected . FTIR Spectra of compounds have been recorded in KBr disk on shimadzu FT-IR-8300 .The 1H-NMR spectra (solvent DMSO-d6¬ )were recorded by Brucker (500MHz) in Jordan using TMS as internal standard. 1 -Synthesis compound ( 1)[17]: 3 ) mmol) from Nalidixic acid with (6mmole) dimethyl sulphate in acetone and (3 mole) potassium carbonate were