vv International Journal of Dermatology and Clinical Research ISSN: 2455-8605 DOI CC By 018 Citation: Sirohi S, Bhutani S, Cheema C, Kaur G, Singh SP, et al. (2017) Comparison of safety and efficacy of Oral Terbinafine with Amphotericin B gel and Sertaconazole cream for the treatment of Tinea Corporis and its effect on quality of life of patients. Int J Dermatol Clin Res 3(1):018-021. DOI: http://doi.org/10.17352/2455-8605.000021 Clinical Group Abstract Background: Tinea Corporis is a superficial fungal infection affecting 20-25% of the world’s population. Management involves using topical and oral antifungal drugs. Terbinafine has been used commonly for the treatment of tinea corporis to prevent the emergence of resistance combination of drugs is used. Hence, this study was designed to compare the safety and efficacy of Sertaconazole and Amphotericin B when either is used with oral Terbinafine. Methodology: This open-label, randomized, prospective and parallel group study was conducted on patients suffering from tinea corporis visiting the Department of Dermatology. All patients underwent a thorough clinical examination to establish the diagnosis of tinea corporis and were divided into two groups. Patients in Group A received treatment with Sertaconazole and Terbinafine. Group B received treatment with Amphotericin B and Terbinafine. At the end of treatment phase patients were assessed clinically for the disease symptoms - erythema, pruritus, and scaling; adverse effects experienced and Dermatological life quality index (DLQI). Results: Fifty two (52) patients were enrolled in the study, both groups were comparable at baseline. After 2 weeks of treatment, complete clinical cure was found in 6 patients in Group A and 5 patients in Group B. The treatment also showed improvement in clinical disease activity as there was clinical improvement seen in 22 patients in group A as compared to 25 patients in Group B. Greater number of patients in Group B reported with symptomatic improvement. There was no serious adverse event reported in both groups and DLQI score was comparable. Conclusion: The use of topical antifungals along with systemic antifungals has been found to be useful in early achievement of clinical cure and improvement in clinical symptoms of tinea corporis. Review Article Comparison of safety and efficacy of Oral Terbinafine with Amphotericin B gel and Sertaconazole cream for the treatment of Tinea Corporis and its effect on quality of life of patients Sumedha Sirohi 1 , Sumit Bhutani 1 , Cherry Cheema 1 , Gurleen Kaur 2 , S P Singh 3 , Prithpal S Matreja 4 * 1 MBBS Student, Fourth Year, Gian Sagar Medical College and Hospital, Village Ram Nagar, District Patiala, Punjab, India-140601 2 Assistant Professor, Department of Pharmacology, Gian Sagar Medical College and Hospital, Village Ram Nagar, District Patiala, Punjab, India-140601 3 Professor & HOD, Department of Dermatology, Gian Sagar Medical College and Hospital, Village Ram Nagar, District Patiala, Punjab, India-140601 4 Professor and Head, Department of Pharmacology, Teerthankar Mahaveer Medical College & Research Center, TMU, Moradabad, 244001, Uttar Pradesh, India Dates: Received: 07 July, 2017; Accepted: 07 September, 2017; Published: 09 September, 2017 *Corresponding author: Prithpal Singh Matreja, Department of Pharmacology, Professor and Head, TeerthankarMahavir Medical College Research Center, TMU Moradabad, UP, India, Tel: +91-9855001847; E-mail: Keywords: Dermatophystosis; Cutaneous; Erythema; Itching; Scaling https://www.peertechz.com Introduction Tinea Corporis is a superficial fungal infection (dermatophytosis) anywhere on the body except the scalp, beard, feet, or hands. Fungal infections of the skin and nails have been found to affect 20-25% of the world’s population, making them one of the most frequent forms of infection [1]. It may occur on any part of the body, and may have a variety of appearances, most easily identifiable by enlarging raised red rings with a central area of clearing [2]. The disease can be acquired by person to person transfer usually via direct skin contact with affected individual. The fungus also spreads by touching inanimate objects like personal care products, bed linen, combs, athletic gear or hair brushes contaminated by affected person [2]. Generally a mild and non- threatening condition, tinea can affect people at any age. Individuals at high risk include those living in crowded or humid conditions, sweat excessively, wear tight constrictive clothing with poor circulation, and have weakened immune system. The quality of life has been shown to be impaired with tinea corporis [3]. The pharmacological management of tinea corporis involves using topical and oral antifungal drugs like allylamines, azoles, polyene antibiotics. The topical agents are more commonly used; the oral drugs being used for extensive lesions [4,5]. Out of the various antifungals, terbinafine and itraconazole