Sneha et al., IJPSR, 2016; Vol. 7(3): 1240-1244. E-ISSN: 0975-8232; P-ISSN: 2320-5148 International Journal of Pharmaceutical Sciences and Research 1240 IJPSR (2016), Vol. 7, Issue 3 (Research Article) Received on 05 September, 2015; received in revised form, 19 November, 2015; accepted, 12 December, 2015; published 01 March, 2016 WOUND HEALING ACTIVITY OF AQUEOUS EXTRACT OF LEPTADENIA RETICULATA IN WISTAR ALBINO RATS B. Sneha*, M. Ganga Raju and Veeresh Babu Department of Pharmacology, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad-500090. Andhra Pradesh, India. ABSTRACT: Herbal medicines have been widely utilized as effective remedies for the prevention and treatment of multiple health conditions for centuries by almost every known culture. Leptadenia reticulata belonging to the family Asclepiadaceae is an important medicinal plant which is used for various ailments. In the present study, an attempt was made to study the wound healing activity of aqueous extract of Leptadenia reticulata (AELR) using excision and burn wound models. In each model, animals were divided into three groups (n=6). Group I served as disease control group, received gel base, group II received AELR gel 10% and group III served as standard and received povidone-iodine 10% ointment. AELR gel 10% showed a significant (P<0.01) in both excision and burn wound models, which was comparable with the standard povidone iodine 10% ointment. Wound healing activity was also confirmed by histopathological studies. The present study suggested that topical application of aqueous extract of Leptadenia reticulata gel 10% plays an important role in wound healing activity. These finding could justify the inclusion of aqueous extract of Leptadenia reticulata in the management of wound healing. INTRODUCTION: Wound is a type of injury in which the skin is torn, cut or punctured (an open wound) or where blunt force trauma causes a contusion (a closed wound) 1 . Wound healing is an intricate process where the skin (or another organ- tissue) repairs itself after injury. Wound healing is divided into three phases: the inflammatory phase, proliferative phase and remodelling phase. Inflammatory phase is characterized by increased blood flow, increased capillary permeability and increased migration of leucocytes into the affected area. QUICK RESPONSE CODE DOI: 10.13040/IJPSR.0975-8232.7(3).1240-44 Article can be accessed online on: www.ijpsr.com DOI link: http://dx.doi.org/10.13040/IJPSR.0975-8232.7 (3).1240-44 Proliferative phase is characterized by granulation, contraction and epithelization. Remodelling phase determines the strength and appearance of the healed area 2 . Leptadenia reticulata belongs to the family Asclepiadaceae. It is commonly called as ‘jiwanti”. It is distributed in tropical and subtropical parts of Asia, Africa, Burma, Srilanka, Philippines and Madagascar. In India it is found in Gujarat, Punjab, Himalayan ranges, konkon, Nilgiris and Southern part of India 3 . Various pharmacological activities of this plant was reported which include hepatoprotective activity, anti-implantation activity, anticarcinogenic activity and anti-fungal activity 4 . The present study was designed to study the effect of aqueous extract of Leptadenia reticulata on wound healing activity. Keywords: Wound healing, Leptadenia reticulata, Excision wound, Burn wound Correspondence to Author: B. Sneha Postgraduate (B. Pharmacy) H. no: 20-1-5, Inside Puranapul, Hyderabad-Telangana state -500064, Andhra Pradesh, India. E-mail: snehabherji@gmail.com