IJPCBS 2013, 3(2), 350-359 Singh Chhater et al. ISSN: 2249-9504 350 I NTERNATI ONAL JOURNAL OF PHARMACEUTI CAL, CHEMI CAL AND BI OLOGI CAL SCI ENCES Available online at www.ijpcbs.com SOLVENT EVAPORATION METHOD FOR AMORPHOUS SOLID DISPERSIONS: PREDICTIVE TOOLS FOR IMPROVE THE DISSOLUTION RATE OF PIOGLITAZONE HYDROCHLORIDE Singh Chhater 1 * and Kumar Praveen 2 1 Shri Venkateshwara University, Rajabpur, Gajraula/ SVU, Uttar Pradesh, India. 2 S.D. College of Pharmacy & Vocational Studies, Muzaffarnagar, Uttar Pradesh, India. 1. INTRODUCTION The formulation of poorly water-soluble drugs has always been a challenging problem faced by pharmaceutical scientists and it is expected to increase because approximately 40% or more of the new chemical entities being generated through drug discovery programs are poorly water-soluble. Pioglitazone is a Thiazolidinedione antidiabetic agent that depends on the presence of insulin for its mechanism of action 1, 2 . Pioglitazone is a potent and highly selective agonist for peroxisome proliferator-activated receptor-gamma (PPARg) 3 . Pioglitazone decreases insulin resistance in the periphery and in the liver resulting in increased insulin-dependent glucose disposal and decreased hepatic glucose output. Pioglitazone HCl is a poor water soluble drug, it is necessary to improve the solubility and bioavailability. There are many techniques that have commonly been used to improve dissolution and bioavailability of poorly water-soluble drugs, which includes the surfactants, micronization, and the formation of solid dispersion. The term solid dispersion refers to the dispersion of one or more active ingredients in an inert carrier or matrix at solid state prepared by the melting (fusion), 4 solvent or the melting-solvent method. Chiou and Riegelmen outlined 6 types of drug carrier 5 interactions in solid state dispersions: simple eutectic mixtures, solid solutions, 6 glass solutions of suspension, 7, 8 compound or complex formations between the drug and the carrier, 8 amorphous precipitations of a drug in a crystalline carrier. 9 Polyvinyl pyrrolidone K30 is most commonly used as a carrier in the solid dispersion system. 10 2. MATERIALS AND METHODS 2.1 Materials Pioglitazone HCl sample from Ontop Pharmaceuticals LTD (Bangalore, India), Polyvinyl pyrrolidone K30 was purchase in the market; all the chemi cals w er e A.R. Gr ade. Research Article ABSTRACT The present study was aimed to improve the solubility of Poorly water soluble drug (pioglitazone HCl), by the solvent evaporation method in order to achieve increased dissolution rate, improved solubility, bioavailability and stability. The main purpose of this investigation was to increase the solubility and dissolution rate of Pioglitazone HCl by the preparation of its solid dispersion with polyvinyl pyrrolidone K30 using solvent evaporation methods. FT- IR spectra revealed no chemical incompatibility between drug and polyvinyl pyrrolidone K30. Drug-polymer interactions were investigated using differential scanning calorimetry (DSC), Powder X-Ray Diffraction (PXRD). Keywords: polyvinyl pyrrolidone K30, solid dispersion, solvent evaporation methods, Pioglitazone HCl.