Page 1 Introduction Erythropoietin (Epo) was investigated whether having antioxidant capacities. 2 histologic variables in anonarianischemia reperfusion (OIR) experiment were tested for this purpose. The one variable was that of ovarian epithelium karyorrhexis (OK), which was non significantly recessed within the “without lesions alterations”grade by 0.0818182+0.06845895 (p-value=0.2246) 1 . The other variable was that of oophoritis (OI) but was significantly enhanced within the “without lesions alterations” grade by 0.1363636+0.0480711 (p-value=0.0057) 2 . Although Epo is met in over 30,569 published biomedical studies, only a 3.57% of them Research Article Open Access American Research Journal of Biomedical Engineering Volume 2, Issue 1, 8 Pages The Co-Evaluation of Ovarian Epithelium Karyorrhexis and Oophoritis after the Erythropoietin Effect on Ovarian Ischemia Reperfusion Injury Constantinos Tsompos 1 *, Constantinos Panoulis 2 , Konstantinos Toutouzas 3 Aggeliki Triantafyllou 4 , George C. Zografos 5 , Kalliopi Tsarea 6 , Maria Karamperi 7 Apostolos Papalois 8 1 *Department of Gynecology, General Hospital of Thessaloniki “St. Dimitrios” Thessaloniki, Hellas. 2 Department of Obstetrics & Gynecology, Aretaieion Hospital, Athens University, Athens, Attiki, Hellas. 3 Department of Surgery, Ippokrateion General Hospital, Athens University, Athens, Attiki, Hellas. 4 Department of Biologic Chemistry, Athens University, Athens, Attiki, Hellas. 5 Department of Surgery, Ippokrateion General Hospital, Athens University, Athens, Attiki, Hellas. 6, 7, 8 Experimental Research Centre ELPEN Pharmaceuticals, S.A. Inc., Co., Pikermi, Attiki, Hellas. *Tsomposconstantinos@gmail.com Abstract Aim: This study co-evaluated the 2 quoted histologic variables after the erythropoietin (Epo) administration. The calculation was based on the results of 2 preliminary studies, each one evaluating a respective histologic variable of ovarian epithelium karyorrhexis (OK) or oophoritis (OI) in an induced ischemia reperfusion animal experiment. Materials and Methods: The 2 main experimental endpoints at which the OK and OI scores were evaluated was the 60 th reperfusion min(for the groups A and C) and the 120 th reperfusion min (for the groups B and D). Specially, the groups A and B were processed without drugs, whereas the groups C and D after Epo administration. Results: The first preliminary study showed that Eponon significantly recessed the ovarian epithelium karyorrhexis (OK) within the “without lesions alterations” grade by 0.0818182 [-0.2159977 - 0.0523614] (p-value=0.2246) 1 . However, the second preliminary study showed that Epo significantly enhanced oophoritis (OI) within the “without lesions alterations” grade by 0.1363636 [0.0421443 - 0.230583] (p-value=0.0057) 2 . These 2 studies were co-evaluated since they came from the same experimental setting. This study investigated the combined diagnostic value of both variables together. Conclusions: Epo has a hardly deteriorating potency of these histologic parameters within the “without lesions alterations” grade by 0.0272727 [-0.0556778 - +0.1102233] (p-value=0.5097) since they were co-evaluated together. Keywords: ischemia, ovarian epitheliumkaryorrhexis, oophoritis, erythropoietin, reperfusion www.arjonline.org