Original Research Article DOI: 10.18231/2394-6792.2018.0008 Indian Journal of Pathology and Oncology, January-March, 2018;5(1):42-45 42 Histopathologic correlates of clinically verrucous lesions Leena Dennis Joseph 1 , C. N. Sai Shalini 2,* , Subalakshmi B. 3 , Divya D. 4 , V. Pavithra 5 1 Professor, 2 Associate Professor, 3,4 Demonstrator, 5 Assistant Professor, Dept. of Pathology, Sri Ramachandra Medical College and Research Institute. Sri Ramachandra University, Chennai *Corresponding Author: Email: saishalini_cn14@yahoo.com Abstract Introduction: Verrucous lesions present as cauliflower like, slowly growing masses, which may be single, multiple or diffuse involving the broad areas of skin or mucosal surfaces. Clinically these lesions are diagnostic challenges. Histopathology remains the gold standard in diagnosing this diverse group of verrucous lesions. The aim of this study was to understand the microscopy of clinically verrucous lesions. Material and Methods: This is a retrospective data of clinically verrucous lesions over the past five years. Clinical details were obtained from the archives and diagnosis was noted from the pathology records. A total of 116 clinically verrucous lesions were included. Results: Majority of the cases were Verruca vulgaris (37 cases), followed by 33 cases of Seborrheic keratosis. There were 12 cases of verrucous carcinoma, seven cases of tuberculosis verrucosa cutis, six cases of verrucous nevus and one case of verrucous hemangioma. The other cases were of varied histology, inspite of clinically verrucous appearance. All the cases were diagnosed purely based on histopathology findings, which show characteristic morphological features, which help the pathologist in the correct diagnosis. Conclusions: Histopathologic confirmation helps in alleviating the anxiety of the patients and helps us to arrive at a correct diagnosis. Keywords: Carcinoma, Papillomatosis, Seborrheic keratosis, Verrucous, Wart. Received: 03 rd July, 2017 Accepted: 19 th August, 2017 Introduction ‘Verrucose’ refers to warty lesions or vegetations on the surface of the skin. Clinically verrucous lesions could be any of the long list of lesions, with a warty surface which includes verruca vulgaris, verrucous carcinoma, seborrheic keratosis, Tuberculosis Verrucosa cutis, verrucous lupus erythematosus, proliferative verrucous leukoplakia. Verrucous nevus or rare entities like verrucous perforating collagenoma, verrucous cyst or a verrucous vascular malformation. Verrucous papillary lesions of the oral cavity are also diagnostic dilemmas, as it involves a broad spectrum of lesions ranging from benign to potentially malignant to frank malignant lesions. Benign spectrum includes squamous papilloma, verruca vulgaris, focal epithelial hyperplasia and condylomas. Verrucous hyperplasias are potentially malignant lesions, which can be differentiated from verrucous carcinoma by the exophytic and endophytic nature of the latter as compared to the pure exophytic lesion of the former. Location can be varied,but the lesion is quite worrisome to the patient, both cosmetically as well as prognostically. Hence a complete excision with a histopathological confirmation is of paramount significance to assist the clinician in initiating appropriate therapy as well as to alleviate the anxiety of the patient. The aim of our study was to study the histopathology of all the clinically verrucous lesions and to categorise them accordingly into relevant groups, so as to understand them better. Material and methods This is a retrospective data of all the lesions with a clinically verrucous surface and which was sent for histopathological evaluation. The clinical data was obtained from the requisition slips that accompanied the biopsy specimens. The histopathology diagnosis was obtained from the archives in the department of Pathology.