Tikrit Journal of Pharmaceutical Sciences 12(2) 2017 ISSN 1817-2716 17 Effect of Using Combined Oral Contraceptive on Thyroid Hormones and Lipid Profile in Female *Wasan S. Oubeid, **Hiba H. Salih, ***Dakhel H. Hadry **** Nawar A. Jasim *,*** Department of physiology and pharmaceutical and chemistry, College of Veterinary medicine, University of Tikrit, Tikri, Iraq ** Department of Pharmacology and Toxicology, College of pharmacy, University of Tikrit, Tikri, Iraq **** Department of pathology and poultry diseases, College of Veterinary medicine, University of Tikrit, Tikri, Iraq Abstract This study was performed to know the effect of contraceptive pill on the thyroid hormone triiodothyronine, thyroxin, and thyroid stimulating hormone, and lipid profile, (total cholesterol, triglyceride, and, high density lipoprotein). Blood samples were collected from 60 women's at the midcycle which divided to two groups, group (A) consist of 30 women taking combined oral contraceptive more than one year. and group (B) which consists 30 women never take oral contraceptive and considered as control group. The age of these women varies from 20 to 35 years. The results of the current study showed that the levels of triiodothyronin and thyroxin were significantly higher among women taking combined contraceptive compared to control group, while the TSH level was significantly lower in group A although it was in the normal range, comparative with control group. The level of triglyceride and total cholesterol were significantly higher in women of group (A) comparative with control group (B), and the HDL level was significantly lower among combined contraceptive users compared to control group. المركبةحمل موانع ال تأثير استخدام ى الدرقية ومستوت الغدة على هرمونا ن الدهولناث لدى ا وسن سرحان عبيد هبة حازم صالح ي دخيل حسين حدرر علي جاسم نواخلصة الاست انذسشيج هز أجعشفت نحفضة نهغذة انت، وانهشيىث انغذة انذسقيا هشيىم عهع انحىب يأثيش حب ح انذسقيت، سخىي وي، انغهسشيذاثانكىنسخشول انكهي( انذهىعج. ج)نكثافتني اي عا انذهلثيت، وانبشوحي انثث انذو يا عي06 هشيت،خصف انذوسة انش يشأة في ايهى حى حقسي( ىعتج، انىعخي يج إنA ي حخكى) 06 ايشأة أخزع يىام انحشكبت ان طشيق انفى ع لت س كثش ي واحذة .( ىعت ويجB انخي) هج ش06 ايشأة نىخذو حسخ وسائ طشيق انفىم عع انح م ي و انخي عذث كشاوحخائج. حت انقاسىعت سيطشة نج جاس اعساء اناست انذس في هز بي06 و03 ت. سسخىي يت فيىيادة يع وجىد صيخائج اظهشث انT3 وT4 في( ىعتج انA ىعتجت يع ان يقاس) B سخىي يا فيىيخفاضا يعئج اخا. وأظهشث ان)ىعت انسيطشةيج( TSH ىعتج في انA جها كا أ انشغى ي عه ضعي،عذل انطبي ان بانىعت انسيطشة.ت يع يجقاس