ISSN 2394-3777 (Print) ISSN 2394-3785 (Online) Available online at www.ijartet.com International Journal of Advanced Research Trends in Engineering and Technology (IJARTET) Vol. 6, Issue 4, April 2019 All Rights Reserved © 2019 IJARTET 36 A Review on Robust Algorithm for Early Detection of Alzheimer’s Disease Anu Rose K P 1 , Ambily Francis 2 M.tech - Embedded Systems, Dept of ECE, Sahrdaya College of Engineering and Technology, Thrissur, India, anupius16@gmail.com 1 Asst. Professor, Dept of ECE, Sahrdaya College of Engineering and Technology, Thrissur, India, ambilyfrancis@sahrdaya.ac.in 2 Abstract: Alzheimer’s disease is a common neurological disorder and it is generally affected in eld erly people. This illness condition creates lots of issues in the affected people. This disease makes a person lose his memory and will have trouble in doing his daily activities, and thus in the advanced stage of this condition leads to death. No treatment is available to completely relieve this disease but it is better if we detect this disease at its earliest stage as necessary aid can be provided. In this review paper we will use Alzheimer’s Disease (AD), Cognitively Normal (CN), Mild Cognitive Impairme nt non- convertible (MCInc) and Mild Cognitive Impairment convertible (MCIc) data. These data are available from the ADNI (Alzheimer’s Disease Neuroimaging Initiative) and they are passed through some of the processes for proper detection. The process includes pre-processing, feature extraction and classification. Different principles are used in each stage and different levels of accuracy are obtained. MCIc is the type of data which leads to Alzheimer’s disease at a later stage. First section in this paper gives general idea about the Alzheimer’s Disease and its associated problems. Second section discusses the detection of early stage of Alzheimer’s Disease with various technologies. Third section includes performance comparison of different techniques. Keywords: AD, CN, MCIc, MCInc I. INTRODUCTION Alzheimer’s disease is a major medical illness condition affecting the elderly people. People who are of the age 65 and above are more suffering from this disease. The persons affected with this disease will lose their natural ease to perform their daily work and are more exposed to memory loss, confusion and later on to death. The person’s affected with Alzheimer’s would initially have MCI and it is difficult to predict, if the MCI would convert into AD or not. There are 100 billion nerve cells in our brain and these neurons have their connection. The brain cells performs many functions and these cells store energy and communicate between them. Alzheimer’s disease is advanced due to the plaques and tangles [3] formed in the brain. Alzheimer’s disease prevents the functionality of cell in the brain. As one region of the brain is affected, it gradually spreads on to the other region. As a result the brain cells will lose their ability to do the work and eventually the person will die. Figure 1.1 shows a healthy brain and Alzheimer’s affected brain. Fig 1.1 Healthy brain and Alzheimer’s affected brain Alzheimer's disease is one of the most common causes that lead to dementia. Dementia is a general term used for memory loss and other cognitive abilities, which are serious enough to interfere with daily life. Alzheimer's disease accounts for 60 percentage to 80 percentage of dementia cases. Symptoms are usually developed slowly and it will