International Journal of Scientific Research in Science and Technology (IJSRST) Print ISSN : 2395-6011, Online ISSN : 2395-602X International Conference on Advanced Materials Held on 14, 15 December 2017, Organized by Department of Physics, St. Joseph’s College, Trichy, Tamilnadu, India Papers presented in ICAM-2017 Conference can be accessed from www.ijsrst.com- Volume 3, Issue 11, November-December-2017 Page | 129 One-pot Synthesis of MPA Capped CdTe Quantum Dots for Non-Enzymatic Hydrogen Peroxide Biosensor Application G. Sindhu 1,2 , M. Manikandan 1 , S. Dhanuskodi 2,* and M.M. Armstrong Arasu 2 1 School of Physics, Bharathidasan University, Tiruchirappalli-620024, India 2 Department of Physics, St. Joseph’s College (Autonomous), Tiruchirappalli-620002, India. *Corresponding Author Email id: dhaus2k3@gmail.com Abstract Mercaptopropionic Acid (MPA) capped CdTe QDs with crystallite size is 0.8 nm were successfully synthesized in aqueous medium by reflux method. The HRSEM demonstrates the spherical shape with varying sizes in the nanometer scales. From the electrochemical studies, the prepared QDs improve the electron transfer between electrode and H2O2. The sensor exhibits a linear range from 0.67-8.04 µM with a sensitivity of 0.2833 mA mM -1 cm -2 with a linear coefficient of 0.9877. The sensor shows detection limit of 6.7 µM with a rapid amperometric response time of 5s and possesses a good reproducibility. It shows the selectivity toward H2O2 and interference free phenomenon for other electro active species like oxalic acid and ascorbic acid. MPA capped CdTe QDs sensor was used in rat and human serum samples and cell labeling. Keywords: CdTe Quantum Dots, Hydrogen peroxide, Sensitivity, Selectivity, Limit of Detection. 1. Introduction Hydrogen peroxide (H2O2) is simplest and colorless peroxide and plays an important role in biological systems. It is widely applicable in biological, industrial, pharmaceutical and environmental [1-3]. H2O2 is not only a byproduct of almost all oxidases in mitochondria and separate out freely through membranes and reaches various cellular components [4]. Many analytical tools such as volumetric, photometry, chemiluminescence, chromatography, flurometric and electrochemical have been employed for the detection of H2O2. Electrochemical method has attracted considerable interest due to high sensitivity, low cost, lower limit detection, less response time, efficiency, linear range and selectivity [5-7]. In last decades the electrochemical biosensor modified with several metal nanomaterial’s and QDs have been studied. The modified TGA capped CdTe QDs based on electrode shows high selective detection of dopamine in the presence of ascorbic acid and uric acid has been proposed by Roushani et al.[8]. Carbon paste electrode modified with CdTe QDs was fabricated and used to study the electro oxidation of dopamine and uric acid in some real samples [9]. II-VI semiconductor nanocrystals also known as quantum dots (QDs) has received extensive attention due to their size dependent optical properties, efficient emission and potential applications in biosensor, nonlinear optics, electronics, light emitting diode, photovoltaic devices, bio imaging and cell labeling [10-12]. In this work, Glassy carbon electrode (GCE) modified with MPA capped CdTe QDs for determination of H2O2 in the presence of excess amount of interfaces like oxalic acid (OA) and ascorbic acid (AA).