www.ijbcp.com International Journal of Basic & Clinical Pharmacology | March 2018 | Vol 7 | Issue 3 Page 518 IJBCP International Journal of Basic & Clinical Pharmacology Print ISSN: 2319-2003 | Online ISSN: 2279-0780 Original Research Article Antihyperlipidemic activity of Chloroxylon swietenia in triton WR1339 induced hyperlipidemia B. H. M. R. K. Guptha 1 , S. L. D. V. Ramana Murty Kadali 2 *, Vijay Kumar M. 3 , Revanasiddappa B. C. 3 INTRODUCTION Hyperlipidemia is a condition characterized by an increase in one or more of the plasma lipids, including triglycerides, cholesterol, cholesterol esters, phospholipids and or plasma lipoproteins including VLDL and LDL along with reduced HDL levels. 1 ABSTRACT Background: Medicinal herbs are beneficial and effective either in the management and prevention of several metabolic disorders, associated with hyperlipidemia, hypertension and insulin resistance which increases the cardio- metabolic risk and demands for the life time therapy. Current allopathic medicines are expensive and reported with several adverse effects and hence, finding of a suitable herbal medicine for hyperlipidemic disorders is very important. Methods: Thirty albino rats weighing 200-230g were randomly divided into 5 groups were rendered hyperlipidemia with a single dose of triton WR 1339. Normal control, positive control, standard, aqueous and ethanolic extract groups were treated with tween-80, tween-80, atorvastatin, aqueous and ethanolic extracts of Chloroxylon swietenia respectively for seven days. At the end of the study, blood was collected for estimation of the lipid profile. Results: Both the aqueous and ethanolic extract groups significantly reduced the TG and VLDL levels. Conclusions: The extracts exhibited remarkable activity on one or either parameter of the lipid profile. It could be due to the presence of alkaloids, steroids, flavonoids, coumarins and phenols in the extracts. Keywords: Chloroxylon swietenia, Hyperlipidemia, Triton WR 1339 DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20180667 1 Department of Pharmacology, IQ City Medical College, Durgapur, West Bengal, India 2 Department of Pharmacology, Modern Institute of Medical Sciences, Indore, Madhya Pradesh, India 3 Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences of Nitte University, Mangalore, India Received: 29 December 2017 Revised: 11 January 2018 Accepted: 29 January 2018 *Correspondence to: Dr. S. L. D. V. Ramana Murty Kadali, Email: murtypharma@ gmail.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open- access article distributed under the terms of the Creative Commons Attribution Non- Commercial License, which permits unrestricted non- commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.