Journal of Pharmacy and Pharmacology 3 (2015) 331-337 doi: 10.17265/2328-2150/2015.07.003 Pharmacological, Microbiological and Derivatographic Studies of the Solid-Dosage Form of the Immunomodulatory Drug Made on the Basis of Bee Products Bohdan Tarasovych Kudrik and Оlexandr Іvanovych Tikhonov Departmant of Pharmacy, National Universitty of Pharmacy, Kharkov 61052, Ukraine Abstract: Pharmacological, derivate and microbiological study of beebread based immunomodulatory drug was conducted. Iimmunomodulating properties of pellets “Apimun” in the form of antibodies formation in response to the EB antigen were studied. Clear immunostimulatory properties of pellets “Apimun” were reproduced in mature rats and mice with normal immune status. Pellets “Apimun” at doses 1.5 and 2.0 g/kg showed increased activity of phagocytosis and processes of antibody formation inhibition of delayed hypersensitivity reactions. Antimicrobial activity of pellets “Apimun” was studied. It was proved that it did not have antimicrobial properties. Derivate studies were conducted and showed that the active substance and composition of the IMP was stable at normal temperature. The results of pharmacological, microbiological and derivate studies show the effectiveness of the pellets “Apimun” and prospects for further research in order to create a product for immune status improvement. Key words: Immune system, immunotropic drugs, immune deficiency, granules, bee bread, apimun, derivatographic studies, microbiological studies. 1. Introduction Provision of an adequate level of immunoprotection which, along with nervous and hormone systems, ensures the smooth functioning of the human body is one of the most essential elements in human health. Today, the human immune system is exposed to extreme loads caused by environmental pollution, ionizing radiation, effects of the Chernobyl accident, AIDS pandemic, etc., that’s why it requires maximum and all-out support. These factors and other crises including one more significant destructive factor, namely stress, have pathogenic effect on the immune system. The pathogenic role of stress increases several times if the immune system is simultaneously exposed to HIV, radiation, and radionuclides of food, thus Corresponding author: Kudryk Bohdan Tarasovych, graduate student, research field: composition and technology of solid dosage form of an immunomodulatory agents based on pollen. E-mail: beepro.pharm@gmail.com. forcing people to live in extremely harsh living conditions without rational social and medical orientation. The things specified above underline the usefulness and importance of developing efficient immunostimulatory drugs. Despite the sufficiently broad range of immunostimulatory drugs, most of them are synthetic drugs (levamisole, T-atkyvin, tymalin, etc.). The use of the latter can lead to exhaustion of the immune system due to an excessive intrusion into its function. Thus, the development of immunomodulatory drugs having a mild and natural effect on the human body remains an important problem of modern medicine and pharmacy. Of particular interest to this matter are standardized drugs of natural origin made on the basis of bee products which differ favorably from synthetic immunistimulators by a biological interaction with tissues of the body. These drugs become more and D DAVID PUBLISHING