_____________________________________________________________________________________________________ *Corresponding author: E-mail: augustineairaodion@yahoo.com; Asian Journal of Research in Medical and Pharmaceutical Sciences 7(2): 1-9, 2019; Article no.AJRIMPS.49325 ISSN: 2457-0745 Efficacy of Combined Crude Extract of Curcuma longa and Moringa oleifera in the Prevention of Peptic Ulcer in Albino Rats Augustine I. Airaodion 1* , Olukunle A. Adekale 2 , Edith O. Airaodion 3 , Emmanuel O. Ogbuagu 4 , Uloaku Ogbuagu 1 and Etinosa U. Osemwowa 5 1 Department of Biochemistry, Federal University of Technology, Owerri, Imo State, Nigeria. 2 Department of Botany, University of Ibadan, Oyo State, Nigeria. 3 Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomoso, Nigeria. 4 Department of Pharmacology and Therapeutics, Abia State University, Uturu, Nigeria. 5 Department of Food Chain and Health, University of Helsinki, Helsinki, Finland. Authors’ contributions This work was carried out in collaboration with all authors. Author AIA conceptualized and designed the study and also wrote the manuscript. Authors OAA and EOA managed the analyses of the study. Author EOO managed the literature searches. Author EUO wrote the protocol while Author UO performed the statistical analysis. All authors read and approved the final manuscript. Article Information DOI: 10.9734/AJRIMPS/2019/v7i230115 Editor(s): (1) Dr. Alex Xiucheng Fan, Professor, Department of Biochemistry and Molecular Biology, University of Florida, USA. (2) Dr. S. Prabhu, Department of Biotechnology, Sri Venkateswara College of Engineering, Sriperumbudur, India. (3) Dr. Somdet Srichairatanakool, Professor, Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand. Reviewers: (1) Bhushan R. Gandhare, Institute of Pharmaceutical Education and Research, India. (2) Nuhu Sambo Human, Baze University, Nigeria. Complete Peer review History: http://www.sdiarticle3.com/review-history/49325 Received 26 March 2019 Accepted 12 June 2019 Published 18 June 2019 ABSTRACT Aim: This study is aimed at investigating the prophylactic efficacy of combined extract of Curcuma longa and Moringa oleifera leaf against indomethacin–induced ulcer in albino rats. Place and Duration of Study: This research was carried out in Ibadan Nigeria between November 2017 and January, 2018. Methods: Fifty (50) healthy male albino rats with body weights between 150 and 200 g were used for this study. They were randomly divided into ten groups of five rats each. Group I was Original Research Article