Research Article Effects of Royal Jelly Administration on Lipid Profile, Satiety, Inflammation, and Antioxidant Capacity in Asymptomatic Overweight Adults Ana Petelin, 1 Saša Kenig, 1 Rok KopinI, 2 MatjaD DeDelak, 2 Maša HerneliI Bizjak, 1 and Zala Jenko PraDnikar 1 1 University of Primorska, Faculty of Health Sciences, Polje 42, SI-6310 Izola, Slovenia 2 Medex d.o.o., Linhartova 49A, SI-1000 Ljubljana, Slovenia Correspondence should be addressed to Zala Jenko Praˇ znikar; zala.praznikar@upr.si Received 15 April 2019; Revised 15 May 2019; Accepted 26 May 2019; Published 13 June 2019 Academic Editor: Juraj Majtan Copyright © 2019 Ana Petelin et al. Tis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objectives. Obesity and overweight are chronic disorders of multifactorial origin that are characterized by high oxidative status and by chronic activation of macrophages in peripheral tissues. Efective therapeutic approaches to lower infammation and oxidative stress are currently of general interest. Royal jelly (RJ) is a functional food with a broad range of pharmacological activities, mainly used by healthy individuals or borderline patients to protect themselves against disease onset. Te objective of this randomized, double-blind, placebo-controlled trial was to investigate the efects of RJ supplementation on metabolic profle and oxidative and infammatory parameters in asymptomatic overweight adults, considered at an early stage of developing metabolic syndrome. Material and Methods. Te experimental group (n=30) was given RJ and the control group (n=30) was provided with a placebo for eight weeks. Anthropometric, biochemical parameters, biomarkers of oxidative stress, and infammation were assessed at baseline, afer 4 and 8 weeks of the intervention, and afer additional 2 weeks of follow up. Results and Conclusion. Compared with the placebo, RJ supplementation demonstrated a statistically signifcant decrease in total cholesterol (6.7%; p=0.041) and infammatory marker C-reactive protein (19%; p=0.027), whereas signifcant increases were observed in anti-infammatory marker adiponectin (34%; p=0.011), endogenous antioxidants bilirubin (35%; p=0.002) and uric acid (5%; p=0.018), total antioxidant capacity in serum (54%; p=0.005), and leptin (17%; p=0.025). Te present study demonstrated positive efects of RJ administration on lipid profle, satiety, infammation, and antioxidant capacity in overweight adults. Terefore, our study supports the benefts of RJ supplementation for the improvement of human health. 1. Introduction Te incidence of obesity has been rapidly increasing, and this condition has become a major public health threat, since it is strongly linked with increased risk for several diseases including type 2 diabetes, cardiovascular disease, cancer, and brain aging [1, 2]. Obesity and overweight are chronic dis- orders of multifactorial origin that are characterized by high oxidative status [3] and by chronic activation of macrophages in peripheral tissues [4, 5]. Activated macrophages yield unresolved infammation in peripheral organs including the adipose tissue [4, 6] and liver [7]. Tus far, molecular mech- anisms underlying obesity and obesity-related metabolic dis- orders have not been fully clarifed, and efective therapeutic approaches to lower infammation and oxidative stress are currently of general interest [8]. In recent years, the consideration of natural products as anti-infammatory and antioxidative treatments has grown worldwide. Moreover, natural products are easily obtained and are relatively safe. Royal jelly (RJ) is a mixture of natural products secreted from the hypopharyngeal and mandibular glands of nurse honeybees (Apis mellifera). It is essential for queen reproduction and larvae development in honeybee colonies. RJ is now widely used as a dietary supplement and in cosmetic products [9] and is as a functional food of interest for the improvement of human health. RJ contains a specifc combination of water, sugars, proteins, and lipids and approximately 90% of RJ lipids are Hindawi Evidence-Based Complementary and Alternative Medicine Volume 2019, Article ID 4969720, 11 pages https://doi.org/10.1155/2019/4969720