Arora Bobina et al.; International Journal of Advance Research, Ideas and Innovations in Technology © 2019, www.IJARIIT.com All Rights Reserved Page |1779 ISSN: 2454-132X Impact factor: 4.295 (Volume 5, Issue 3) Available online at: www.ijariit.com A review on mouth dissolving tablets of Glimepiride Bobina Arora arorabobina09@gmail.com Swami Vivekanand College of Pharmacy, Banur, Punjab Prerna Sarup psarup_pu@hotmail.com Swami Vivekanand College of Pharmacy, Banur, Punjab Sonia Pahuja pharmsoniapahuja@gmail.com Swami Vivekanand College of Pharmacy, Banur, Punjab Navneet Kaur nkgill1115443@gmail.com Swami Vivekanand College of Pharmacy, Banur, Punjab ABSTRACT The oral route is considered as the most common and preferred technique for drug administration because it is considered as the easiest and simplest method. The route provides the simplicity of drug administration in a handy way and individuals tend to be more knowledgeable about this particular route. The latest developments in Novel Drug Delivery System (NDDS) seeks for improving effectiveness and molecules security that was used previously by preparing suitable dosage forms for administration. Nowadays the problems such as dysphagia are faced by the conventional dosage forms like capsules and tablets, which results in ineffective therapy because of the high incidence of non-compliance. Mouth dissolving tablets (MDTs) were developed to prevent the above issues in conventional dosage forms. These MDTs have easy administration, dose uniformity, and good hardness as well as are the first preference for travelling, geriatric, and pediatric patients. This paper provides a review for MDT because of its wide significance, as well as such a drug delivery system may help for better compliance of patient along with ultimate clinical output. Keywords— Mouth Dissolving Tablets (MDT), Orally disintegrating tablets, Super-disintegrate 1. INTRODUCTION In today’s existing dosage form these tablets are mostly used form due to manufacturing ease, compactness and self -administration. Nevertheless, mental, pediatric and geriatrically ill individuals’ encounters trouble in swallowing traditional capsules that is normal amongst most age groups, particularly in aged that results to bad patient conformity (Gosh et al., 2011). In order to conquer these issues, scientists have created a revolutionary medication distribution process referred to as mouth disintegrating or dissolving pills. This particular doses disintegrates and dissolves in the mouth in just a few minutes without any chewing or even water. This particular invention is helpful in medication administration of geriatric and pediatric patients (Kumar et al., 2011). 1.1 Advantages of mouth dissolving tablets  Geriatric, pediatric, as well as institutionalized patients (especially psychiatric or mentally retarded patients), can administrate easily.  Easier handling by patients, small packaging size, easy manufacturing, accurate dosing and good stability is provided by the MDT as they are unit solid dosage forms.  Various sweeteners and flavors are used in MDT due to which it is easily palatable.  The travelling patients that do not have water access are benefitted by such tablets as the dosage obstruction risk is eliminated.  Quick onset action is provided as this tablet disintegrates quickly which results in quick absorption and dissolution. 1.2 Challenges in developing MDT  The tablet should not disintegrate rapidly  Tablet size should not be increased  Mechanical strength should be sufficient  Least or no residue in the mouth  Moisture protection  Not affected by drug properties (Bharadwaj et al., 2010)